Evidence map›Paper›PMID 37736013›Full record

ArticleWellcome open research2023

Inferring causal genes at type 2 diabetes GWAS loci through chromosome interactions in islet cells.

Jason M Torres, Han Sun, Vibe Nylander, Damien J Downes, Martijn van de Bunt, Mark I McCarthy, Jim R Hughes, Anna L Gloyn

Open access · greenAbstract read
In one paragraph

Article in Wellcome open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Jason M TorresWellcome Centre for Human Genetics, University of Oxford, Oxford, England, OX3 7BN, UK.ORCID https://orcid.org/0000-0002-7537-7035
Han SunDepartment of Pediatrics, Division of Endocrinology and Diabetes, Stanford University School of Medicine, Stanford, CA, 94305, USA.
Vibe NylanderOxford Centre for Diabetes Endocrinology & Metabolism, University of Oxford, Oxford, England, OX3 7L3, UK.
Damien J DownesMedical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9D2, UK.
Martijn van de BuntWellcome Centre for Human Genetics, University of Oxford, Oxford, England, OX3 7BN, UK.ORCID https://orcid.org/0000-0002-6744-6125
Mark I McCarthyWellcome Centre for Human Genetics, University of Oxford, Oxford, England, OX3 7BN, UK.
Jim R HughesMedical Research Council Molecular Haematology Unit, Medical Research Council Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, OX3 9D2, UK.
Anna L GloynWellcome Centre for Human Genetics, University of Oxford, Oxford, England, OX3 7BN, UK.
Centre for Human Genetics · GBMRC Weatherall Institute of Molecular Medicine · GBOxford Centre for Diabetes, Endocrinology and Metabolism · GBStanford Medicine · US

Funding

Bridging the gap between type 2 diabetes GWAS and therapeutic targetsUM1DK126185 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CLAUSSNITZER, MELINA C, GLOYN, ANNA LOUISE · 2020 to 2024
$9.5M
Identifying variants causal for Type 2 Diabetes in Major human populationsU01DK085545 · NIDDK · UNIVERSITY OF OXFORD · PI CHAN, JULIANA CN, EBRAHIM, SHAH BRIAN · 2009 to 2013
$2.8M
Integrating genome-scale data to reveal causal mechanisms in type 2 diabetesU01DK105535 · NIDDK · UNIVERSITY OF OXFORD · PI GLOYN, ANNA LOUISE · 2015 to 2019
$1.7M
Medical Research Council MC_UU_00016/1Medical Research Council MC_UU_00016/14Medical Research Council MC_UU_00029/3Medical Research Council MR/N00969X/1NIDDK NIH HHS U01 DK085545NIDDK NIH HHS U01 DK105535NIDDK NIH HHS UM1 DK126185Wellcome Trust
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Capture-Cchromatin interactionsEndoC-βH1 cellsgenetic regulationGWAS locihuman isletstype 2 diabetes

Identifiers

PMID37736013
PMCPMC10509606
OpenAlexW4386944907

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.