ArticleJournal of enzyme inhibition and medicinal chemistry2023
Design, synthesis, conformational analysis, and biological activity of Cα
Francesca Nuti, Maud Larregola, Agnieszka Staśkiewicz, Bernhard Retzl, Nataša Tomašević, Lorenzo Macchia, Maria E Street, Michał Jewgiński, Olivier Lequin, Rafal Latajka and 4 more
Open access · goldAbstract read
In one paragraphArticle in Journal of enzyme inhibition and medicinal chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed, 2 citations in OpenAlex.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
14 authors at 6 institutions in 8 countries.
Francesca NutiInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Florence, Italy.ORCID 0000-0001-9908-5996 Maud LarregolaCNRS, BioCIS, CY Cergy Paris Université, Cergy Pontoise and Paris Saclay Université, Orsay, France.ORCID 0000-0002-9196-3552 Agnieszka StaśkiewiczInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Florence, Italy.ORCID 0000-0003-2111-6726 Bernhard RetzlInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-7764-7046 Nataša TomaševićInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-1887-4008 Lorenzo MacchiaInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Florence, Italy.ORCID 0009-0003-6223-8292 Maria E StreetDipartimento di Medicina e Chirurgia, Università di Parma e Clinica Pediatrica, AOU di Parma, Parma, Italy.ORCID 0000-0001-8427-8971 Michał JewgińskiDepartment of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wrocław, Poland.ORCID 0000-0003-4931-5452 Olivier LequinLaboratoire des Biomolécules, Sorbonne Université, Ecole Normale Supérieure, PSL University, CNRS, Paris, France.ORCID 0000-0001-5307-3068 Rafal LatajkaDepartment of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Wrocław, Poland.ORCID 0000-0003-2943-2838 Paolo RoveroInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of NeuroFarBa, University of Florence, Sesto Fiorentino, Florence, Italy.ORCID 0000-0001-9577-5228 Christian W GruberInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-6060-7048 Michael ChorevLaboratory for Translational Research, Department of Medicine, Division of Hematology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-3533-2913 Anna Maria PapiniInterdepartmental Research Unit of Peptide and Protein Chemistry and Biology, Department of Chemistry "Ugo Schiff", University of Florence, Sesto Fiorentino, Florence, Italy.ORCID 0000-0002-2947-7107 University of Florence · ITInstitute of Pharmacology · CZWrocław University of Science and Technology · PLCentre National de la Recherche Scientifique · FRBrigham and Women's Hospital · USUniversity of Parma · IT
Funding
Austrian Science Fund FWF P 32109
6 · The paper itselfAbstract
Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited amongst others by disadvantageous pharmacokinetic parameters. To increase the stability of OT by replacing the disulphide bridge with the stable and more rigid [1,2,3]triazol-1-yl moiety, we employed the Cu
Indexed as
AlkynesOxytocinAzidesCatalysisDisulfidesAlkynesAzidesDisulfidesOxytocinCuAACdisulphide replacementintramolecular macrocyclisationOxytocinβ-turn conformation
Identifiers
PMID37735942
PMCPMC10519257
OpenAlexW4386945023
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC
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