ArticleAnnals of clinical and translational neurology2023
The role of quantitative markers in surgical prognostication after stereoelectroencephalography.
Article in Annals of clinical and translational neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pooled it
- Functional Segregation of Epileptogenicity within the Human Amygdala.Annals of neurology · 2026Article
- 50 Hz Cortical stimulation increases interictal epileptiform discharges at the seizure onset zone.Brain communications · 2026Article
- Medial pulvinar stereoelectroencephalographic biomarkers associated with deep brain stimulation response in focal drug-resistant epilepsy.Epilepsia · 2026Article
- Collapse of interictal suppressive networks permits seizure spread.Brain : a journal of neurology · 2025Article
- Performance of blind source separation in localizing seizure onset from routine scalp-EEG.Journal of neurology · 2025Article
- Mapping Postictal Aphasia through Signal Complexity: A Stereo-Electroencephalography Study.Annals of neurology · 2025Article
- Cerebral Cavernous Malformations and Focal Drug-Resistant Epilepsy: Behind a Quid Pro Quo of Lesion and Epileptogenic Networks.European journal of neurology · 2025Article
- Stereoelectroencephalographic exploration and surgical outcome in Lennox-Gastaut syndrome.Epilepsia · 2025Article
- Can brain network analyses guide epilepsy surgery?Current opinion in neurology · 2025Review
- SEEG in 2025: progress and pending challenges in stereotaxy methods, biomarkers and radiofrequency thermocoagulation.Current opinion in neurology · 2025Review
- Epileptogenic zone characteristics determine effectiveness of electrical transcranial stimulation in epilepsy treatment.Brain communications · 2025Article
- Interictal waking and sleep electrophysiological properties of the thalamus in focal epilepsies.Brain communications · 2025Article
- The role of the thalamus in focal human epilepsy: insights from stereoelectroencephalography (SEEG).Frontiers in neurology · 2025Review
- Spikes on ripples are better interictal biomarkers of epilepsy than spikes or ripples.Brain communications · 2025Article
- Impact of post-traumatic stress disorder on epileptogenic networks: a functional connectivity study.Scientific reports · 2024Article
- Combining independent component analysis and source localization for improving spatial sampling of stereoelectroencephalography in epilepsy.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveStereoelectroencephalography (SEEG) is the reference method in the presurgical exploration of drug-resistant focal epilepsy. However, prognosticating surgery on an individual level is difficult. A quantified estimation of the most epileptogenic regions by searching for relevant biomarkers can be proposed for this purpose. We investigated the performances of ictal (Epileptogenicity Index, EI; Connectivity EI, cEI), interictal (spikes, high-frequency oscillations, HFO [80-300 Hz]; Spikes × HFO), and combined (Spikes × EI; Spikes × cEI) biomarkers in predicting surgical outcome and searched for prognostic factors based on SEEG-signal quantification.
methodsFifty-three patients operated on following SEEG were included. We compared, using precision-recall, the epileptogenic zone quantified using different biomarkers (EZ
resultsEI and Spikes × EI showed the best precision against EZ
interpretationIctal or combined ictal-interictal markers overperformed the interictal markers both for detecting the EZ and predicting seizure freedom. Combining ictal and interictal epileptogenicity markers improves detection accuracy. Resection rates of the quantified EZ using ictal markers were the only statistically significant determinants for surgical prognosis.
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