ArticleParasites & vectors2023
Pharmacokinetics of fluralaner as a systemic drug to control infestations of the common bed bug, Cimex lectularius, in poultry facilities.
Article in Parasites & vectors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 9 citations in OpenAlex.
- Residue depletion and withdrawal period determination of fluralaner in edible tissues and eggs following oral administration in laying Hens.Poultry science · 2026Article
- Long-term efficacy of fluralaner (ExzoltParasites & vectors · 2026Article
- Fluralaner, an innovative ectoparasiticide for use in cattle: UFLC-MS/MS method development and validation for its pharmacokinetic characterization.Veterinary research communications · 2026Article
- Mechanics of dust bathing in birds.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Toxicity of ivermectin to bed bugs (Cimex hemipterus) and risk factors associated with infestation in Kwale County, coastal Kenya.Parasites & vectors · 2025Article
- Deployment and transcriptional evaluation of nitisinone, an FDA-approved drug, to control bed bugs.Pest management science · 2025Article
- One Health, many approaches: integrated vector management strategies support One Health goals.Frontiers in insect science · 2025Review
- Next-generation neuropeptide Y receptor small-molecule agonists inhibit mosquito-biting behavior.Parasites & vectors · 2024Article
- Lethal, Sublethal, and Offspring Effects of Fluralaner and Dinotefuran on Three Species ofInsects · 2024Article
- Insecticidal activity of fluralaner (ExzoltParasites & vectors · 2024Article
- Next Generation Neuropeptide Y Receptor Small Molecule Agonists Inhibit Mosquito Biting Behavior.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundBed bug infestations are re-emerging in the poultry industry throughout the USA. Although the impacts of bed bugs on birds' health and welfare are poorly understood, adverse outcomes are expected, including stress, anemia, infections and lower production rates. Worker welfare is also an important consideration in commercial poultry farms. A limited number of insecticides are available for use in the complex spatial environment of commercial farms. Systemic drugs have the potential to overcome the limitations of existing pest management tactics. A recent study showed that fluralaner administered to chickens caused high levels of mortality in bed bugs.
methodsTo further understand the efficacy of this approach, we evaluated the pharmacokinetics of an oral solid formulation of fluralaner in 11 chickens and quantified its plasma concentration in chickens using UPLC/MS. We administered fluralaner to chickens with two doses of Bravecto
resultsBed bugs that fed on fluralaner-treated chickens experienced > 50% mortality within 30 min of the administration of Bravecto and 100% mortality 2 days post-treatment. Mortality slowly declined to 66.6% by day 28. Fluralaner was quantifiable in the hens' plasma for at least 28 days post-treatment. The treatment resulted in maximal plasma concentrations (C
conclusionsFluralaner appears to be a promising candidate for bed bug control in poultry farms, with a treatment effect lasting at least 28 days.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.