Evidence map›Paper›PMID 37735641›Full record

ArticleBMC pediatrics2023

Sex steroid hormones and allergic diseases in children: a pilot birth cohort study in the Japan Environment and Children's Study cohort.

Yumiko Miyaji, Kiwako Yamamoto-Hanada, Limin Yang, Mayako Saito-Abe, Miori Sato, Hidetoshi Mezawa, Minaho Nishizato, Masayuki Ochiai, Shouichi Ohga, Masako Oda and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Landscape of Aeroallergen Sensitization in Asia.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 1 country.

Yumiko MiyajiAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Kiwako Yamamoto-HanadaAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan. yamamoto-k@ncchd.go.jp.
Limin YangMedical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Mayako Saito-AbeAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Miori SatoAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Hidetoshi MezawaMedical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Minaho NishizatoMedical Support Center for the Japan Environment and Children's Study, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Masayuki OchiaiDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Shouichi OhgaDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masako OdaThe South Kyushu Okinawa Unit Center, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hiroshi MitsubuchiDepartment of Neonatology, Kumamoto University Hospital, Kumamoto, Japan.
Masayuki ShimonoRegional Center for Pilot Study of Japan Environment and Children's Study, University of Occupational and Environmental Health, Fukuoka, Japan.
Reiko SugaRegional Center for Pilot Study of Japan Environment and Children's Study, University of Occupational and Environmental Health, Fukuoka, Japan.
Nathan MiseDepartment of Environmental and Preventive Medicine, Jichi Medical University, Tochigi, Japan.
Makiko SekiyamaJapan Environment and Children's Study Programme Office, National Institute for Environmental Studies, Ibaraki, Japan.
Shoji F NakayamaJapan Environment and Children's Study Programme Office, National Institute for Environmental Studies, Ibaraki, Japan.
Yukihiro OhyaAllergy Center, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-Ku, Tokyo, 157-8535, Japan.
Japan Environment and Children’s Study (JECS)
National Center For Child Health and Development · JPKyushu University · JPNational Institute for Environmental Studies · JPUniversity of Occupational and Environmental Health Japan · JPJichi Medical University · JPKumamoto University · JPKumamoto University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNumerous studies suggest that sex steroids might play a role in sex disparity observed in allergic diseases in adults. However, whether sex hormones influence allergic diseases in children remains unclear. The aim of the present study was to examine the association of sex steroid hormones with allergic disease in Japanese children.

methodsThe present cross-sectional study included 145 6-year-old children participating in a pilot birth cohort study in the Japan Environment and Children's Study. Data on allergic diseases were obtained from questionnaires, and serum levels of sex steroid hormones and allergen-specific IgE were measured. Logistic regression was performed to evaluate the association of sex hormones with allergic diseases.

resultsAfter adjusted sex, amount of body fat at 6 years, parental history of allergic disease, and exposure to tobacco smoke, serum dehydroepiandrosterone sulfate level was significantly associated with reduced odds of any allergic disease (adjusted odds ratio, 0.58; 95% confidence interval, 0.36-0.93; P = 0.024) and serum follicle-stimulating hormone level was significantly associated with increased odds of any allergic disease (adjusted odds ratio, 2.04; 95% confidence interval, 1.01-4.11, P = 0.046). Dehydroepiandrosterone sulfate level showed a significant association with number of allergic diseases.

conclusionsThe current study findings suggest that sex hormones may play an important role in the development of allergic diseases in prepubertal children.

Indexed as

HypersensitivityAdultChildCohort StudiesCross-Sectional StudiesDehydroepiandrosterone SulfateGonadal Steroid HormonesHumansJapanDehydroepiandrosterone SulfateGonadal Steroid HormonesAllergic diseaseAsthmaAtopic dermatitisDehydroepiandrosterone sulfateFollicle-stimulating hormoneSex steroid hormone

Identifiers

PMID37735641
PMCPMC10512488
OpenAlexW4386929336

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.