ArticleNature neuroscience2023
Somatostatin neurons in prefrontal cortex initiate sleep-preparatory behavior and sleep via the preoptic and lateral hypothalamus.
Article in Nature neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 68 citations in OpenAlex.
- Brain stimulation techniques as novel treatment options for insomnia: A systematic review.Journal of sleep research · 2023Pooled it
- The altered hypothalamic network functional connectivity in chronic insomnia disorder and regulation effect of acupuncture: a randomized controlled neuroimaging study.BMC complementary medicine and therapies · 2024Trial
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- A male-biased hypothalamic circuit modulates postmating sleep suppression in mice.Science advances · 2026Article
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- Sleep circuit modulation: from animal models to human translation.Brain : a journal of neurology · 2026Review
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- Sex-specific organization and synaptic signaling in prefrontal-hypothalamic circuitry.bioRxiv : the preprint server for biology · 2026Article
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- A brainstem-thalamocortical circuit mediates postoperative pain duration induced by sleep deprivation.Behavioral and brain functions : BBF · 2026Article
- Disrupted temperature-sleep coupling mechanism in a Dravet syndrome mouse model.Nature communications · 2026Article
- Electrophysiological effects of psilocybin co-administered with midazolam.Translational psychiatry · 2026Article
- The DMHAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Efficacy and mechanism of combined treatment with transcranial direct current stimulation and zolpidem for treatment-resistant insomnia: a study protocol for a prospective, double-blind, randomized controlled trial.Frontiers in psychiatry · 2026Article
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- Brain-Region-Mediated Neuroimmune Modulation in Sepsis: Research Advances and Therapeutic Prospects.Journal of inflammation research · 2026Review
- Intestinal bacteria trigger a hibernation-like state in homotherms via the gut-brain axis.NPJ biofilms and microbiomes · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
The prefrontal cortex (PFC) enables mammals to respond to situations, including internal states, with appropriate actions. One such internal state could be 'tiredness'. Here, using activity tagging in the mouse PFC, we identified particularly excitable, fast-spiking, somatostatin-expressing, γ-aminobutyric acid (GABA) (PFC
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.