Evidence map›Paper›PMID 37735449›Full record

ReviewJournal of nanobiotechnology2023

Functional roles of magnetic nanoparticles for the identification of metastatic lymph nodes in cancer patients.

Yuanliang Yan, Yuanhong Liu, Tongfei Li, Qiuju Liang, Abhimanyu Thakur, Kui Zhang, Wei Liu, Zhijie Xu, Yuzhen Xu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of nanobiotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Yuanliang YanDepartment of Pharmacy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Yuanhong LiuDepartment of Pharmacy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Tongfei LiHubei Key Laboratory of Embryonic Stem Cell Research, School of Basic Medical Sciences, Hubei University of Medicine, 442000, Shiyan, Hubei, China.
Qiuju LiangDepartment of Pharmacy, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Abhimanyu ThakurPritzker School of Molecular Engineering, Ben May Department for Cancer Research, University of Chicago, 60637, Chicago, IL, USA.
Kui ZhangPritzker School of Molecular Engineering, Ben May Department for Cancer Research, University of Chicago, 60637, Chicago, IL, USA.
Wei LiuDepartment of Pathology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China.
Zhijie XuDepartment of Pathology, Xiangya Hospital, Central South University, 410008, Changsha, Hunan, China. xzj1322007@csu.edu.cn.
Yuzhen XuDepartment of Rehabilitation, The Second Affiliated Hospital of Shandong First Medical University, 271000, Taian, Shandong, China. tianyayizhe@126.com.
Central South University · CNUniversity of Chicago · USHubei University of Medicine · CNShandong First Medical University · CNXiangya Hospital Central South University · CN

Funding

National Natural Science Foundation of China 82272659Science and Technology Program of Hunan Province 2021RC3029Science and Technology Program of Hunan Province 2022RC1210
6 · The paper itself

Abstract

Staging lymph nodes (LN) is crucial in diagnosing and treating cancer metastasis. Biotechnologies for the specific localization of metastatic lymph nodes (MLNs) have attracted significant attention to efficiently define tumor metastases. Bioimaging modalities, particularly magnetic nanoparticles (MNPs) such as iron oxide nanoparticles, have emerged as promising tools in cancer bioimaging, with great potential for use in the preoperative and intraoperative tracking of MLNs. As radiation-free magnetic resonance imaging (MRI) probes, MNPs can serve as alternative MRI contrast agents, offering improved accuracy and biological safety for nodal staging in cancer patients. Although MNPs' application is still in its initial stages, exploring their underlying mechanisms can enhance the sensitivity and multifunctionality of lymph node mapping. This review focuses on the feasibility and current application status of MNPs for imaging metastatic nodules in preclinical and clinical development. Furthermore, exploring novel and promising MNP-based strategies with controllable characteristics could lead to a more precise treatment of metastatic cancer patients.

Indexed as

Magnetite NanoparticlesNeoplasmsBiotechnologyHumansLymph NodesPhysical PhenomenaMagnetite NanoparticlesBioimagingCancer diagnosis and treatmentIron oxideMagnetic nanoparticlesMetastatic lymph nodes

Identifiers

PMID37735449
PMCPMC10512638
OpenAlexW4386932945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.