Evidence map›Paper›PMID 37735264›Full record

ArticleNature biotechnology2024

Detecting organelle-specific activity of potassium channels with a DNA nanodevice.

Palapuravan Anees, Anand Saminathan, Ezekiel R Rozmus, Anke Di, Asrar B Malik, Brian P Delisle, Yamuna Krishnan

Open access · greenAbstract read
In one paragraph

Article in Nature biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Organelles harbour pH gradients.Research square · 2026
    Article
  7. Organelles harbour pH gradients.bioRxiv : the preprint server for biology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Metal Ion Signaling in Biomedicine.Chemical reviews · 2025
    Review
  14. Article
  15. Review
  16. Article
  17. Quantitative Chemical Imaging of Organelles.Accounts of chemical research · 2024
    Article
  18. The ion channels of endomembranes.Physiological reviews · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Palapuravan AneesDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Anand SaminathanDepartment of Chemistry, The University of Chicago, Chicago, IL, USA.
Ezekiel R RozmusDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA.
Anke DiDepartment of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine, Chicago, IL, USA.
Asrar B MalikDepartment of Pharmacology and Regenerative Medicine, The University of Illinois College of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-8205-7128
Brian P DelisleDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA. brian.delisle@uky.edu.ORCID http://orcid.org/0000-0002-2146-327X
Yamuna KrishnanDepartment of Chemistry, The University of Chicago, Chicago, IL, USA. yamuna@uchicago.edu.ORCID http://orcid.org/0000-0001-5282-8852
University of Chicago · USIllinois College · USUniversity of Kentucky · US

Funding

Synthetic Biology and Optogenetics CoreP01HL151327 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI KARGINOV, ANDREI V · 2021 to 2025
$11.8M
Intracellular Electrophysiology: An electrochemical atlas of organellesDP1GM149751 · NIGMS · UNIVERSITY OF CHICAGO · PI KRISHNAN, YAMUNA · 2022 to 2025
$5.7M
Mechanism and function of intracellular sodium-proton exchangersR01GM147197 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KRISHNAN, YAMUNA, MIRSHAHI, TOORAJ · 2022 to 2025
$2.4M
Calcium homeostasis in organellesR01NS112139 · NINDS · UNIVERSITY OF CHICAGO · PI KRISHNAN, YAMUNA · 2020 to 2024
$1.8M
Mechanisms that alter Potassium channel trafficking in arrhythmiasR21HL161825 · NHLBI · UNIVERSITY OF CHICAGO · PI KRISHNAN, YAMUNA · 2022 to 2023
$448k
A mechanism of lysosomal Calcium entryR21NS114428 · NINDS · UNIVERSITY OF CHICAGO · PI KRISHNAN, YAMUNA · 2019 to 2020
$408k
Human Frontier Science Program (HFSP) RGP0032/2022NHLBI NIH HHS P01 HL151327NHLBI NIH HHS R21 HL161825NIGMS NIH HHS DP1 GM149751NIGMS NIH HHS R01 GM147197NINDS NIH HHS R01 NS112139NINDS NIH HHS R21 NS114428United States Department of Defense | United States Air Force | AFMC | Air Force Office of Scientific Research (AF Office of Scientific Research) FA9550-19-0003U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) R21HL161825-01A1U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 1R01GM147197-01U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) DP1GM149751U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 1R01NS112139-01A1
6 · The paper itself

Abstract

Cell surface potassium ion (K

Indexed as

OrganellesDNAEndosomesHumansHydrogen-Ion ConcentrationPotassiumPotassium ChannelsDNAPotassiumPotassium Channels

Identifiers

PMID37735264
PMCPMC11021130
OpenAlexW4386923897

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.