Evidence map›Paper›PMID 37735213›Full record

ArticleClinical oral investigations2023

Antineoplastic therapy in childhood cancer patients presents a negative impact in the periodontal tissues: a cohort study.

Bruna C Longo, Isabel B Rohling, Pauline L M O E Silva, Maria E F de Morais, Hélvis E S Paz, Renato C V Casarin, Sheila A B Nishiyama, Maria D B de Souza, Cléverson O Silva

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Article in Clinical oral investigations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Bruna C LongoDepartment of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil.
Isabel B RohlingDepartment of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil.
Pauline L M O E SilvaDepartment of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil.
Maria E F de MoraisDepartment of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil.
Hélvis E S PazDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
Renato C V CasarinDepartment of Prosthodontics and Periodontics, Piracicaba Dental School, University of Campinas, Piracicaba, SP, Brazil.
Sheila A B NishiyamaDepartment of Basic Health Sciences, State University of Maringá (UEM), Maringá, Paraná, Brazil.
Maria D B de SouzaDepartment of Dentistry, State University of Western Parana (UNIOESTE), Cascavel, Paraná, Brazil.
Cléverson O SilvaDepartment of Dentistry, State University of Maringá (UEM), Av. Mandacaru, 1550, Campus Universitário, Maringá, Paraná, Brazil. prof.cleversonsilva@gmail.com.ORCID https://orcid.org/0000-0002-7103-9100
Universidade Estadual de Maringá · BRUniversidade Estadual do Oeste do Paraná · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the effect of antineoplastic therapy (AT) in the periodontal tissues of childhood cancer (CC) patients. MATERIALS AND

methodsSeventy-two individuals were divided into CC (n=36) and healthy individuals (control group-CG, n=36). Demographics, hygiene habits, CC type, and AT were collected. Salivary flow and the presence and concentration of Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Tannerella forsythia, and Fusobacterium nucleatum were analyzed. Clinical evaluation included plaque (PI) and gingival indexes (GI), periodontal probing depth (PPD), and clinical attachment level (CAL). Patients were classified into periodontal health, gingivitis, or periodontitis. Descriptive statistics, T test, Mann-Whitney test, chi-square, Fisher's exact test, and two-way analysis of variance were used (p<0.05).

resultsThe mean age of the patients was similar (CC 12.0±3.9 years and CG 12.0±4.0 years). In the CC group, all patients underwent chemotherapy and nine radiotherapy. Color/race, income, and family education showed significant differences between groups. There was no difference between groups in salivary flow. Higher levels of Fusobacterium nucleatum were seen in CC (p=0.02). Significant difference between groups was found for PI (CC: 30.5%, CG: 22.6%), GI (CC: 28.8%, CG: 17.3%), PPD (CC: 1.77 mm, CG: 1.61 mm), and CAL (CC: 1.77 mm, CG: 1.57 mm), periodontal health (CC: 3, CG: 7), gingivitis (CC: 16, CG: 24), or periodontitis (CC: 17, CG: 5).

conclusionAT in CC patients presents a negative impact in the periodontal and microbiological parameters. CLINICAL RELEVANCE: Childhood cancer individuals showed worse periodontal parameters and higher levels of Fusobacterium nucleatum in the saliva when compared to healthy individuals.

Indexed as

Antineoplastic AgentsGingivitisNeoplasmsPeriodontitisAdolescentAggregatibacter actinomycetemcomitansChildCohort StudiesFusobacterium nucleatumHumansPeriodontal PocketPorphyromonas gingivalisAntineoplastic AgentsAntineoplastic protocolsCancer survivorsFusobacterium nucleatumOral healthPeriodontal diseases

Identifiers

PMID37735213
OpenAlexW4386913033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.