Trial reportThe European respiratory journal2023
Hypoxic burden to guide CPAP treatment allocation in patients with obstructive sleep apnoea: a
Trial report in The European respiratory journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07792746 (Impact of Obstructive Sleep Apnea Biomarkers on Adherence to Continuous Positive Airway Pressure), which is not on this map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Obstructive Sleep Apnea Biomarkers on Adherence to Continuous Positive Airway Pressure: Role of Pulse Wave Amplitude Drop Index, Hypoxic Burden, and Heart Rate Variability
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Positive airway pressure therapy and all-cause and cardiovascular mortality in people with obstructive sleep apnoea: a systematic review and meta-analysis of randomised controlled trials and confounder-adjusted, non-randomised controlled studies.The Lancet. Respiratory medicine · 2025Pooled it
- The Hypoxic Burden, Clinical Implication of a New Biomarker in the Cardiovascular Management of Sleep Apnea Patients: A Systematic Review.Reviews in cardiovascular medicine · 2024Pooled it
- OSA and Acute Coronary Syndrome Severity: The Potential Role of Coronary Collateral Circulation.Chest · 2026Trial
- Trial
- Cardiovascular Risk Through Hypoxic Burden in Children With Sleep Apnea: A Secondary Analysis of a Nonrandomized Clinical Trial.JAMA network open · 2025Trial
- Arousal threshold modifies the effect of CPAP on executive function among individuals with obstructive sleep apnoea.The European respiratory journal · 2025Trial
- Hypoxic burden reduction after lateral pharyngoplasty in patients with obstructive sleep apnea: Beyond the apnea-hypopnea index.Sleep & breathing = Schlaf & Atmung · 2026Observational
- Oxygen overshoot burden of central sleep apnea and its association with cardiovascular outcomes.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
- Cardiovascular risk stratification in obstructive sleep apnea: a potential role for cardiac troponins.Sleep · 2026Article
- Predicting optimal CPAP pressure in obstructive sleep apnea among Chinese patients using respiratory endotype derived from polysomnography.Scientific reports · 2026Article
- Enhanced Risk Stratification of Atrial Fibrillation Detected After Ischemic Stroke and TIA: The Role of Apnoea-Hypopnoea Index and Hypoxic Burden-A Study From the Bern Sleep-Stroke Registry.Journal of sleep research · 2026Article
- Orforglipron for the treatment of moderate-to-severe obstructive sleep apnea in adults with obesity or overweight: Study design and baseline characteristics of ATTAIN-OSA, a phase 3 trial.Contemporary clinical trials communications · 2026Article
- Review
- The Intersection of Cardiology and Sleep Medicine: Impact of Sleep-Disordered Breathing on Heart Failure Outcomes.Journal of clinical medicine · 2026Review
- Mechanisms of upper airway muscle control in sleep reveal therapeutic targets for obstructive sleep apnea.American journal of respiratory cell and molecular biology · 2026Review
- Hypoglossal Nerve Stimulation and Hypoxic Burden in Patients With Obstructive Sleep Apnea: A Secondary Analysis of the STAR Trial.JAMA otolaryngology-- head & neck surgery · 2026Article
- Article
- Heterogeneity of vascular inflammation in obstructive sleep apnea: effects of continuous positive airway pressure therapy.Annals of the American Thoracic Society · 2026Article
- Continuous Positive Airway Pressure Therapy Alters Monocyte Activation and Immune Phenotype in Obstructive Sleep Apnea in Relation to Hypoxic Burden.Clinical and experimental otorhinolaryngology · 2026Article
- Respiratory Inductance Plethysmography to Quantify Changes in Ventilation in Obstructive Sleep Apnea.IEEE transactions on bio-medical engineering · 2026Article
Corrections and comments
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Authors and funding
27 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundHypoxic burden (HB) has emerged as a strong predictor of cardiovascular risk in obstructive sleep apnoea (OSA). We aimed to assess the potential of HB to predict the cardiovascular benefit of treating OSA with continuous positive airway pressure (CPAP).
methodsThis was a
resultsThe population (362 patients assigned to CPAP and 365 patients assigned to usual care) was middle-aged (mean age 59.7 years), overweight/obese and mostly male (84.5%). A significant interaction was found between the treatment arm and the HB categories. In the high HB group, CPAP treatment was associated with a significant reduction in the incidence of cardiovascular events (HR 0.57, 95% CI 0.34-0.96). In the low HB group, CPAP-treated patients exhibited a trend toward a higher risk of cardiovascular outcomes than those receiving usual care (HR 1.33, 95% CI 0.79-2.25). The differential effect of the treatment depending on the baseline HB level followed a dose-response relationship.
conclusionIn non-sleepy ACS patients with OSA, high HB levels were associated with a long-term protective effect of CPAP on cardiovascular prognosis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.