ArticleThe American journal of drug and alcohol abuse2024
Are you thinking what I'm thinking? Defining what we mean by "polysubstance use."
Article in The American journal of drug and alcohol abuse, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 35 citations in OpenAlex.
- Co-Use of Some Substances Associated With Higher Doses in Adolescents: Findings From the Adolescent Brain Cognitive Development Study.The Journal of adolescent health : official publication of the Society for Adolescent Medicine · 2026Article
- Substance use patterns from late childhood to mid-adolescence: Updates on the Adolescent Brain Cognitive Development Study.Drug and alcohol dependence reports · 2026Article
- A population-based study exploring racial and gender inequities in polysubstance-related deaths across the United States from 2004 to 2022.Addiction (Abingdon, England) · 2026Article
- Latent Class Analysis of Substance Use Behaviors and Associations of Class Membership With Gender Affirmation, Social Determinants of Health, and HIV Status Among Transfeminine Adults in the Eastern and Southern United States.Journal of studies on alcohol and drugs · 2026Article
- Polysubstance use in Canada: prevalence, patterns, and self-reported harms from the 2023 Canadian Substance Use Survey.BMC public health · 2026Article
- The Polysubstance Assessment Tool: Reliability, acceptability and feasibility of a novel measure of polysubstance use.Addiction (Abingdon, England) · 2026Article
- Associations of cannabis, alcohol, and tobacco use combinations with sleep health.Addictive behaviors reports · 2026Article
- Social, Economic, and health risks among people who use Methamphetamine: Comparing three patterns of opioid Co-Use.Addictive behaviors reports · 2026Article
- Polysubstance use in adolescents: conceptual issues and the need for a new public health framework and approach.Psychological medicine · 2026Article
- Crack/cocaine use to manage xylazine exposure in fentanyl in Connecticut: findings from a convergent mixed methods study.Harm reduction journal · 2026Article
- Patterns of polysubstance use among people who use drugs on an American Indian reservation of a southern plains Tribal Nation.Harm reduction journal · 2026Article
- The role of polysubstance use in the development, maintenance, and treatment of stimulant use disorders.Pharmacological reviews · 2026Review
- Celebrating each success: proportion of remission as a measure of recovery from polysubstance use disorder proportion of remission; a recovery measure.Harm reduction journal · 2026Article
- Patterns of polysubstance use disorder among human trafficking survivors: A latent class analysis.Addictive behaviors · 2026Article
- Enhancing data compatibility in an evolving landscape: Medical cannabis and polysubstance use protocols in the PhenX Toolkit.Drug and alcohol dependence · 2026Article
- Disproportionate use of polysubstance combinations varies by sexual identity among US adults.PloS one · 2026Article
- Alcohol and Cannabis co-use and HIV risk, Treatment and Prevention Outcomes: A Scoping Review.Current addiction reports · 2026Article
- Refining a Novel Measure of Polysubstance Use: Applying the Cognitive Interview Method with People Who Use Drugs.Substance use & misuse · 2026Article
- US drug policy does not align with experts' rankings of drug harms: a multi-criteria decision analysis.Harm reduction journal · 2025Article
- Preferences and predictors driving opioid-involved polysubstance use profiles and trajectories: a prospective cohort study protocol.BMJ open · 2025Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
The rise in drug overdoses and harms associated with the use of more than one substance has led to increased use of the term "polysubstance use" among researchers, clinicians, and public health officials. However, the term retains no consistent definition across contexts. The current authors convened from disciplines including sociology, epidemiology, neuroscience, and addiction psychiatry to propose a recommended definition of polysubstance use. An iterative process considered authors' formal and informal conversations, insights from relevant symposia, talks, and conferences, as well as their own research and clinical experiences to propose the current definition. Three key concepts were identified as necessary to define polysubstance use: (1) substances involved, (2) timing, and (3) intent. Substances involved include clarifying either (1) the number and type of substances used, (2) presence of more than one substance use disorder, or (3) primary and secondary substance use. The concept of timing is recommended to use clear terms such as simultaneous, sequential, and same-day polysubstance use to describe short-term behaviors (e.g., 30-day windows). Finally, the concept of intent refers to clarifying unintentional use or exposure when possible, and greater attention to motivations of polysubstance use. These three components should be clearly defined in research on polysubstance use to improve consistency across disciplines. Consistent definitions of polysubstance use can aid in the synthesis of evidence to better address an overdose crisis that increasingly involves multiple substances.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.