Evidence map›Paper›PMID 37733908›Full record

ArticleAutophagy2024

ER stress elicits non-canonical CASP8 (caspase 8) activation on autophagosomal membranes to induce apoptosis.

Tatsuya Hattori, Kevin A Fundora, Kouta Hamamoto, David M Opozda, Xinwen Liang, Xiaoming Liu, Jiawen Zhang, Yasin Uzun, Yoshinori Takahashi, Hong-Gang Wang

Open access · hybridAbstract read
In one paragraph

Article in Autophagy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
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  4. Review
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  6. DDIT3 drives nucleus pulposus cell PANoptosis and intervertebral disc degeneration progression.Apoptosis : an international journal on programmed cell death · 2026
    Article
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  8. Article
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Tatsuya HattoriDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0001-6743-9411
Kevin A FundoraDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-4412-8124
Kouta HamamotoDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0003-3012-3573
David M OpozdaDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-6045-3090
Xinwen LiangDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0009-0002-2319-4912
Xiaoming LiuDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.
Jiawen ZhangDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-6129-7341
Yasin UzunDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0003-3478-3499
Yoshinori TakahashiDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0002-8004-4817
Hong-Gang WangDivision of Pediatric Hematology and Oncology, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA, USA.ORCID 0000-0003-0551-0571
Pennsylvania State University · US

Funding

Non-canonical Caspase-8 Activation on Autophagosomal MembranesR01CA222349 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI HONG-GANG WANG · 2018 to 2026
$3.0M
Autophagosome closure by the ESCRT machineryR01GM127954 · NIGMS · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI WANG, HONG-GANG · 2018 to 2025
$2.7M
NCI NIH HHS R01 CA222349NIGMS NIH HHS R01 GM127954
6 · The paper itself

Abstract

The

Indexed as

NeoplasmsNF-kappa BApoptosisAutophagyCaspase 8Endoplasmic Reticulum StressEndosomal Sorting Complexes Required for TransportHumansRNA, Guide, CRISPR-Cas SystemsCASP8 protein, humanCaspase 8Endosomal Sorting Complexes Required for TransportNF-kappa BRNA, Guide, CRISPR-Cas SystemsATF4-mediated ER stress responseautophagyESCRT-mediated phagophore closureiDISC-mediated apoptosisNFKB/NF-kB signalingVPS37A-deficient cancer

Identifiers

PMID37733908
PMCPMC10813646
OpenAlexW4386916802

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.