SynthesisPloS one2023
Incidence of adverse cardiovascular events in patients with insomnia: A systematic review and meta-analysis of real-world data.
Synthesis in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Dose-response relationship between physical activity and subjective sleep quality in patients with insomnia: a systematic review and Bayesian meta-analysis of randomized controlled trials.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- Assessing the Feasibility and Efficacy of Pre-Sleep Dim Light Therapy for Adults with Insomnia: A Pilot Study.Medicina (Kaunas, Lithuania) · 2024Trial
- Insomnia and stroke risk: A systematic review with meta-analysis of analytical observational studies and mendelian randomization studies.Sleep medicine: X · 2026Article
- Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Insomnia and Cardiovascular Disease: Untangling a Complex Relationship.Journal of sleep research · 2026Review
- Prevalence and Determinants of Poor Sleep Quality Among Patients with Established Coronary Heart Disease in Kazakhstan: A Multi-Center Cross-Sectional Study.Medical sciences (Basel, Switzerland) · 2026Article
- Vital Exhaustion in Hospitalized Patients with Cardiovascular Disease: Associations with Anxiety and Insomnia-A Cross-Sectional Study.Journal of cardiovascular development and disease · 2026Article
- Insomnia symptoms in women and men after percutaneous coronary intervention - a prospective multicentre cohort study.Journal of patient-reported outcomes · 2026Observational
- Sleep Duration and Mortality in Women: Effect of Aging and Menopause.Sleep medicine clinics · 2026Review
- Article
- Mechanisms Linking Insomnia and Cardiometabolic Disease Risk.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Physical factor therapies for insomnia: a narrative review of mechanisms, clinical evidence, and phenotype-guided applications.Frontiers in psychiatry · 2026Review
- Association between sleep duration and co-existing chronic conditions in adults: insights from the 2017-2018 Canadian Community Health Survey.Frontiers in sleep · 2026Article
- Causal association between sleep duration, daytime napping, sleep disorders and ischemic heart disease: A systematic review and meta‑analysis of Mendelian randomization studies.International journal of cardiology. Heart & vasculature · 2025Review
- Diagnosis, treatment, and associated outcomes of later-life insomnia: a narrative review.Sleep · 2025Review
- Sleep Disruption and Atrial Fibrillation: Evidence, Mechanisms and Clinical Implications.Circulation research · 2025Review
- Insomnia Phenotypes, Cardiovascular Risk and Their Link to Brain Health.Circulation research · 2025Review
- Cardiovascular Outcome in Patients with Major Depression: Role of Obstructive Sleep Apnea Syndrome, Insomnia Disorder, and COMISA.Life (Basel, Switzerland) · 2024Article
- Impact of real-world implementation of evidence-based insomnia treatment within a large payor-provider health system: initial provider and patient-level outcomes.Sleep advances : a journal of the Sleep Research Society · 2024Article
- Ayurvedic Interventions for Primary Insomnia in the Elderly: A Systematic Review of Clinical Evidence and Research Gaps.Global advances in integrative medicine and healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insomnia is a prevalent sleeping disorder associated with increasing cardiovascular (CV) mortality and morbidity. However, data incorporating recent clinical studies evaluating these outcomes is scarce. Hence, we aimed to investigate the association of insomnia with CV mortality, myocardial infarction (MI), all-cause mortality, and incidence of CV disease by conducting the first-ever meta-analysis of real-world data evaluating these CV outcomes. MEDLINE and Scopus databases were queried till August 2022 to identify studies comparing prespecified outcomes in patients with and without insomnia. The primary outcomes were CV mortality and myocardial infarction, while secondary outcomes included all-cause mortality, and CV-disease incidence. All data were pooled using an inverse-variance weighted random-effects model, and results were reported as relative risks (RRs) and p-values. 21 studies were analyzed. Risks for CV mortality and MI were significantly higher in patients with insomnia (RR 1.53, p<0.01, and RR 1.48, p = 0.03, respectively). The risk for all-cause mortality and CV disease incidence was also significantly higher in insomnia patients (RR 1.14, p = 0.03, and RR 1.31, p<0.01, respectively). Individuals with insomnia experience a higher risk of long-term mortality, MI, and incidence of CV disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.