Evidence map›Paper›PMID 37733666›Full record

ArticlePloS one2023

Nicotine flux as a powerful tool for regulating nicotine delivery from e-cigarettes: Protocol of two complimentary randomized crossover clinical trials.

Ahmad El-Hellani, Elyana Hanna, Mehak Sharma, Reagan Blohowiak, Phillip Joseph, Tore Eid, Haleh Nadim, Rachel El-Hage, Rola Salman, Nareg Karaoghlanian and 9 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05430334 nacompletednot on this map

Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes: Significance of Nicotine Flux to the Rate of Nicotine Delivery and Subjective Effect

TypeinterventionalSponsorAmerican University of Beirut Medical CenterRan2022 to 2025Enrolled130ConditionsNicotine Vaping, Nicotine Dependence, Nicotine AddictionArmse-liquid 1, e-liquid 2, e-liquid 3, e-liquid 4, e-liquid 5
NCT05706701 nacompletednot on this map

Nicotine Flux, a Potentially Powerful Tool for Regulating Nicotine Delivery From Electronic Cigarettes

TypeinterventionalSponsorYale UniversityRan2023 to 2024Enrolled36ConditionsNicotine VapingArmsNicotine vaping visit 1 (free-base nicotine), Nicotine vaping visit 1 (protonated nicotine), Nicotine vaping visit 2 (free-base nicotine), Nicotine vaping visit 2 (protonated nicotine)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Ahmad El-HellaniDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, United States of America.ORCID 0000-0002-1047-0597
Elyana HannaDepartment of Mechanical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon.
Mehak SharmaSection of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.
Reagan BlohowiakSection of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.
Phillip JosephSection of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.
Tore EidDepartment of Laboratory Medicine, Yale School of Medicine, Washington, DC, United States of America.
Haleh NadimDepartment of Laboratory Medicine, Yale School of Medicine, Washington, DC, United States of America.
Rachel El-HageCenter for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Rola SalmanDepartment of Mechanical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon.
Nareg KaraoghlanianDepartment of Mechanical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon.
Ayomipo AdenijiDivision of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio, United States of America.
Sally SalamCenter for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Farid TalihClinical Psychiatry, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Martine ElbejjaniClinical Research Institute & Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
Alison BrelandCenter for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Thomas EissenbergCenter for the Study of Tobacco Products, Virginia Commonwealth University, Richmond, Virginia, United States of America.
Alan ShihadehDepartment of Mechanical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon.
Stephen R BaldassarriSection of Pulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, Connecticut, United States of America.
Soha TalihDepartment of Mechanical Engineering, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon.
Virginia Commonwealth University · USYale University · USAmerican University of Beirut · LBThe Ohio State University · US

Funding

Project 4: Using a prospective cohort survey to test population-level predictions generated by Projects 1-3U54DA036105 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI FAGAN, PEBBLES · 2018 to 2022
$20.8M
Nicotine flux, a potentially powerful tool for regulating nicotine delivery from electronic cigarettes: significance of nicotine flux to the rate of nicotine delivery and subjective effectsR01DA052565 · NIDA · AMERICAN UNIVERSITY OF BEIRUT · PI EL HELLANI, AHMAD, TALIH, SOHA · 2022 to 2024
$1.3M
Understanding Factors that Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine ReceptorsK23DA045957 · NIDA · YALE UNIVERSITY · PI BALDASSARRI, STEPHEN · 2018 to 2022
$983k
NIDA NIH HHS K23 DA045957NIDA NIH HHS R01 DA052565NIDA NIH HHS U54 DA036105
6 · The paper itself

Abstract

introductionElectronic cigarette (EC) use has increased rapidly in the last decade, especially among youth. Regulating nicotine delivery from ECs could help curb youth uptake and leverage EC use in harm reduction yet is complicated by varying device and liquid variables that affect nicotine delivery. Nicotine flux, the nicotine emission rate, is a parameter that incorporates these variables and focuses on the performance rather than the design of an EC. Nicotine flux therefore could be a powerful regulatory tool if it is shown empirically to predict nicotine delivery and subjective effects related to dependence. METHODS AND ANALYSIS: This project consists of two complementary clinical trials. In Trial I, we will examine the relationship between nicotine flux and the rate and dose of nicotine delivery from ECs, hence, impacting abuse liability. It will also examine the extent to which this relationship is mediated by nicotine form (i.e., freebase versus protonated). At Yale School of Medicine (YSM), study participants will puff EC devices under conditions that differ by flux and form, while arterial blood is sampled in high time resolution. In Trial II, we will assess the relationship between nicotine flux, form, and subjective effects. At the American University of Beirut (AUB), participants will use EC devices with varying nicotine fluxes and forms, while dependency measures, such as the urge to use ECs, nicotine craving, and withdrawal symptoms, will be assessed. We will also monitor puffing intensity and real-time exposure to toxicants. ETHICS AND DISSEMINATION: The protocol of Trial I and Trial II was approved by YSM and AUB IRBs, respectively. We will disseminate study results through peer-reviewed publications and conference presentations.

trial registrationNCT05706701 for Trial I and NCT05430334 for Trial II.

Indexed as

Electronic Nicotine Delivery SystemsNicotineAdolescentBiological TransportCravingCross-Over StudiesHumansNicotine

Identifiers

PMID37733666
PMCPMC10513228
OpenAlexW4386921080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.