Evidence map›Paper›PMID 37733590›Full record

ArticleCell reports2023

Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner.

Yueqi Zhang, Xinhui Liu, Kairui Sun, Yue Luo, Jack Yang, Aimin Li, Matti Kiupel, Stefanie Fenske, Martin Biel, Qing-Sheng Mi and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Yueqi ZhangDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA; Cell and Molecular Biology Program, Michigan State University, East Lansing, MI 48824, USA.
Xinhui LiuDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA; Cancer Center, Southern Medical University, Guangzhou, Guangdong 510315, China.
Kairui SunDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA; College of Osteopathic Medicine, Michigan State University, East Lansing, MI 48824, USA.
Yue LuoDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA; Cancer Center, Southern Medical University, Guangzhou, Guangdong 510315, China.
Jack YangDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Aimin LiDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA; Cancer Center, Southern Medical University, Guangzhou, Guangdong 510315, China.
Matti KiupelDepartment of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI 48824, USA.
Stefanie FenskeDepartment of Pharmacy - Center for Drug Research, Ludwig-Maximilians Universität München, 81377 München, Germany.
Martin BielDepartment of Pharmacy - Center for Drug Research, Ludwig-Maximilians Universität München, 81377 München, Germany.
Qing-Sheng MiImmunology Program, Henry Ford Cancer Institute, Henry Ford Health, Detroit, MI 48202, USA; Center for Cutaneous Biology and Immunology, Department of Dermatology, Henry Ford Health, Detroit, MI 48202, USA.
Hongbing WangDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA.
Hua XiaoDepartment of Physiology, Michigan State University, East Lansing, MI 48824, USA; Cell and Molecular Biology Program, Michigan State University, East Lansing, MI 48824, USA. Electronic address: xiaoh@msu.edu.
Michigan State University · USSouthern Medical University · CNLudwig-Maximilians-Universität München · DEHenry Ford Health System · US

Funding

Role of NCOA5 in hepatic steatosis and hepatocarcinogenesisR01CA188305 · NCI · MICHIGAN STATE UNIVERSITY · PI XIAO, HUA · 2015 to 2019
$1.7M
NCI NIH HHS R01 CA188305
6 · The paper itself

Abstract

Sex differences in hepatocellular carcinoma (HCC) development are regulated by sex and non-sex chromosomes, sex hormones, and environmental factors. We previously reported that Ncoa5

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAnimalsCyclic Nucleotide-Gated Cation ChannelsFemaleHumansHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsMaleMiceNuclear Receptor CoactivatorsPotassium ChannelsTranscription FactorsCyclic Nucleotide-Gated Cation ChannelsHCN3 protein, humanHCN3 protein, mouseHyperpolarization-Activated Cyclic Nucleotide-Gated ChannelsNCOA5 protein, mouseNuclear Receptor CoactivatorsPotassium ChannelsTranscription FactorsCP: CancerHCN3liver cancerNCOA5sex disparity in cancerTIP30

Identifiers

PMID37733590
PMCPMC10873026
OpenAlexW4386880786

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.