Evidence map›Paper›PMID 37733244›Full record

ArticleMolecular diversity2024

QSAR analysis of five generations of cephalosporins to establish the structural basis of activity against methicillin-resistant and methicillin-sensitive Staphylococcus aureus.

Jessica R Morán-Díaz, Francisco Neveros-Juárez, Mónica Griselda Arellano-Mendoza, Delia Quintana-Zavala, Omar Lara-Salazar, José Guadalupe Trujillo-Ferrara, J Alberto Guevara-Salazar

Abstract read
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In one paragraph

Article in Molecular diversity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jessica R Morán-DíazOrganic Chemistry Laboratory. Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada, Unidad Legaria, Instituto Politécnico Nacional, Legaria No. 694, C.P. 11500, Mexico City, Mexico.
Francisco Neveros-JuárezDepartment of Pharmacology, Biochemistry and Section of Postgraduate Studies and Research. Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, S/N, Col. Santo Tomás, Alcaldía Miguel Hidalgo, C.P. 11340, Mexico City, Mexico.
Mónica Griselda Arellano-MendozaChronic-Degenerative Diseases Laboratory and Section of Postgraduate Studies and Research. Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, S/N, Col. Santo Tomás, Alcaldía Miguel Hidalgo, C.P. 11340, Mexico City, Mexico.
Delia Quintana-ZavalaOrganic Chemistry Laboratory. Centro de Investigación en Ciencia Aplicada y Tecnología Avanzada, Unidad Legaria, Instituto Politécnico Nacional, Legaria No. 694, C.P. 11500, Mexico City, Mexico.
Omar Lara-SalazarDisruptive Films S.A. de C.V, Department of Analysis and Data Science, Dr. Andrade 458, Col. Atenor Salas, C.P. 03010, Mexico City, Mexico.
José Guadalupe Trujillo-FerraraDepartment of Pharmacology, Biochemistry and Section of Postgraduate Studies and Research. Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, S/N, Col. Santo Tomás, Alcaldía Miguel Hidalgo, C.P. 11340, Mexico City, Mexico.
J Alberto Guevara-SalazarDepartment of Pharmacology, Biochemistry and Section of Postgraduate Studies and Research. Escuela Superior de Medicina, Instituto Politécnico Nacional, Plan de San Luis y Díaz Mirón, S/N, Col. Santo Tomás, Alcaldía Miguel Hidalgo, C.P. 11340, Mexico City, Mexico. jguevaras@ipn.mx.

Funding

Consejo Nacional de Ciencia y Tecnología 257364Secretaría de Investigación y Posgrado, Instituto Politécnico Nacional 20181505, 20201778, 20201402
6 · The paper itself

Abstract

Solving the worldwide problem of growing bacterial drug resistance will require a short-run and medium-term strategy. Structure-activity relationship (SAR) and quantitative SAR (QSAR) analyses have recently been utilized to reveal the molecular basis of the antibacterial activity and antibacterial spectrum of penicillins, the use of which is no longer solely empirical. Likewise, a more rational drug design can be achieved with cephalosporins, the largest group of β-lactam antibiotics. The current contribution aimed to establish the molecular and physicochemical basis of the antibacterial activity of five generations of cephalosporins on methicillin-sensitive (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). With SAR and QSAR analyses, the molecular portions that provide essential and additional antibacterial activity were identified. The substitutions with greater volume and polarity on the R

Indexed as

Anti-Bacterial AgentsCephalosporinsMethicillin-Resistant Staphylococcus aureusQuantitative Structure-Activity RelationshipMicrobial Sensitivity TestsStaphylococcus aureusAnti-Bacterial AgentsCephalosporinsAntibacterial activityAntibacterial spectrumCephalosporinsPhysicochemical propertiesQSAR

Identifiers

PMID37733244

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.