Evidence map›Paper›PMID 37733227›Full record

ArticleAging clinical and experimental research2023

Inflammation, mitochondrial dysfunction and physical performance: a possible association in older patients with persistent atrial fibrillation-the results of a preliminary study.

Stefano Fumagalli, Giulia Ricciardi, Claudia Di Serio, Giancarlo La Marca, Giuseppe Pieraccini, Riccardo Franci Montorzi, Emanuele Santamaria, Giulia Spanalatte, Francesca Marchetti, Ginevra Corti and 2 more

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Article in Aging clinical and experimental research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Stefano FumagalliDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence, Largo G. Brambilla 3, 50134, Florence, Italy. stefano.fumagalli@unifi.it.ORCID http://orcid.org/0000-0002-6950-3875
Giulia RicciardiDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence, Largo G. Brambilla 3, 50134, Florence, Italy.
Claudia Di SerioDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence, Largo G. Brambilla 3, 50134, Florence, Italy.
Giancarlo La MarcaDepartment of Experimental and Clinical Biomedical Sciences 'Mario Serio', Newborn Screening, Clinical Chemistry and Pharmacology Lab, Meyer Children's Hospital and University of Florence, Florence, Italy.
Giuseppe PieracciniDepartment of Health Sciences, CISM Mass Spectrometry Centre, University of Florence, Florence, Italy.
Riccardo Franci MontorziDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence, Largo G. Brambilla 3, 50134, Florence, Italy.
Emanuele SantamariaDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence, Largo G. Brambilla 3, 50134, Florence, Italy.
Giulia SpanalatteDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence, Largo G. Brambilla 3, 50134, Florence, Italy.
Francesca MarchettiDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence, Largo G. Brambilla 3, 50134, Florence, Italy.
Ginevra CortiDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence, Largo G. Brambilla 3, 50134, Florence, Italy.
Laura PintonDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence, Largo G. Brambilla 3, 50134, Florence, Italy.
Niccolò MarchionniDepartment of Experimental and Clinical Medicine, Geriatric Intensive Care Unit and Geriatric Arrhythmia Unit, University of Florence, Largo G. Brambilla 3, 50134, Florence, Italy.
University of Florence · ITMeyer Children's Hospital · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) is associated with chronic inflammation, a hallmark of ageing process. The aim of this study was to determine interleukin-6 (IL-6)-associated variables, also exploring acylcarnitines, expression of mitochondrial abnormalities.

methodsWe evaluated 22 controls and 50 patients with persistent AF. IL-6 and acylcarnitines were measured with ELISA kits and mass spectrometry techniques.

resultsIL-6 concentration (mean: 3.9 ± 3.1 pg/mL) was lower in controls and increased in AF patients, especially with heart failure. The CHA

conclusionsIn older AF patients, IL-6 correlated with acylcarnitines and lower physical performance. Alterations in energy production, reduced physical function and inflammation could contribute to frailty development.

Indexed as

Atrial FibrillationStrokeAgedHumansInflammationInterleukin-6MitochondriaRisk AssessmentRisk FactorsInterleukin-6AcylcarnitinesAtrial fibrillationElderlyFrailtyIL-6Inflammation

Identifiers

PMID37733227
OpenAlexW4386910230

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.