ArticleJournal of clinical microbiology2023
A head-to-head comparison of three MALDI-TOF mass spectrometry systems with 16S rRNA gene sequencing.
Article in Journal of clinical microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Moraxella peritoneal dialysis-related infections: a systematic review.Jornal brasileiro de nefrologiaPooled it
- Resolution of MALDI-TOF MS compared to whole genome sequencing for the identification of Vibrio parahaemolyticus strains isolated from oysters.Archives of microbiology · 2026Article
- Evaluating the Autof MS2600 vs. Biotyper Sirius MALDI-TOF MS: a head-to-head study for routine microbial identification in a university clinical microbiology laboratory.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Evaluation of the VITEKEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Small is big: growing impact of small molecule mass spectrometry in infectious disease drug development.mSphere · 2026Review
- Establishment of a matrix-assisted laser desorption/ionization time-of-flight mass spectrometry database and evaluation of different methods for cluster analysis of marine bacteria.Journal of medical microbiology · 2026Article
- Article
- A dual-phase strategy to integrate the VITEK MS RUO database into routine clinical practice: from validation of analytical performance to implementation of an automated workflow.Frontiers in cellular and infection microbiology · 2026Article
- Comparative analysis of milk bacteria by two MALDI-MS systems.Scientific reports · 2025Article
- Article
- Evaluation of the identification performance of MALDI-TOF MS Smart MS 5020 from Zhuhai DL Biotech.Microbiology spectrum · 2025Article
- Identification of Filamentous Fungi: An Evaluation of Three MALDI-TOF Mass Spectrometry Systems.Mycoses · 2025Article
- Temporal dynamics and interrelations of cytokines, neutrophil proteins, exudation, and bacterial colonization in epidermal wound healing.Frontiers in medicine · 2025Article
- Case Report: Multiple intra-abdominal lymph node abscesses due toFrontiers in veterinary science · 2025Article
- A comparison of two MALDI-TOF MS based assays for the detection of carbapenemases in Enterobacterales.Scientific reports · 2024Article
- Clinical Evaluation of VITEK MS PRIME with PICKME Pen for Bacteria and Yeasts, and RUO Database for Filamentous Fungi.Microorganisms · 2024Article
- The usefulness of the MALDI-TOF MS technique in the determination of dairy samples' microbial composition: comparison of the new EXS 2600 system with MALDI Biotyper platform.Archives of microbiology · 2024Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has revolutionized diagnostics in culture-based microbiology. Commonly used MALDI-TOF MS systems in clinical microbiology laboratories are MALDI Biotyper (Bruker Daltonics) and Vitek MS (bioMérieux), but recently the new EXS2600 (Zybio) has been launched. This study aimed to evaluate the performance of the three devices by comparing the results to 16S rRNA gene sequencing. A set of 356 previously collected difficult-to-identify bacteria was tested in parallel with the three systems. Only the direct smear method and simple formic acid extraction were applied. Valid results were achieved for 98.6%, 94.4%, and 93.3% of all isolates by MALDI Biotyper, EXS2600, and Vitek MS, respectively. Of all valid results, agreement with sequencing data was achieved in 98.9%, 98.5%, and 99.7% by MALDI Biotyper, EXS2600, and Vitek MS, respectively. Considering only the isolates with valid measurements at the single-species level, misidentification rates were 0%, 2.6%, and 1.1% for MALDI Biotyper, EXS2600, and Vitek MS, respectively. Apart from minor performance differences, our data demonstrate that the three systems provide comparable results and are suitable for use in medical diagnostic laboratories.
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