Evidence map›Paper›PMID 37732266›Full record

ArticlemedRxiv : the preprint server for health sciences2023

A blood biomarker of accelerated aging in the body associates with worse structural integrity in the brain: replication across three cohorts.

Ethan T Whitman, Calen P Ryan, Wickliffe C Abraham, Angela Addae, David L Corcoran, Maxwell L Elliott, Sean Hogan, David Ireland, Ross Keenan, Annchen R Knodt and 10 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 4 countries.

Ethan T WhitmanDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Calen P RyanButler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, USA.
Wickliffe C AbrahamDepartment of Psychology, University of Otago, Dunedin, New Zealand.
Angela AddaeDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
David L CorcoranDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Maxwell L ElliottDepartment of Psychology, Center for Brain Science, Harvard University, Cambridge, MA, USA.
Sean HoganDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
David IrelandDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Ross KeenanBrain Research New Zealand-Rangahau Roro Aotearoa, Centre of Research Excellence, Universities of Auckland and Otago, New Zealand.
Annchen R KnodtDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Tracy R MelzerBrain Research New Zealand-Rangahau Roro Aotearoa, Centre of Research Excellence, Universities of Auckland and Otago, New Zealand.
Richie PoultonDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Sandhya RamrakhaDunedin Multidisciplinary Health and Development Research Unit, Department of Psychology, University of Otago, Dunedin, New Zealand.
Karen SugdenDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Benjamin S WilliamsDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Jiayi ZhouButler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, USA.
Ahmad R HaririDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Daniel W BelskyButler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, USA.
Terrie E MoffittDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Avshalom CaspiDepartment of Psychology and Neuroscience, Duke University, Durham, NC, USA.
Duke University · USUniversity of Otago · NZColumbia University · USBrain Research New Zealand · NZHarvard University · USUniversity of North Carolina at Chapel Hill · US

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
FRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8M
Temporal Trends, Novel Imaging and Molecular Characterization of Preclinical and Clinical Alzheimer's Disease in the Framingham CohortsR01AG054076 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI DECARLI, CHARLES, SESHADRI, SUDHA · 2016 to 2020
$12.3M
Quantifying Individual Differences in Midlife Structural Brain Integrity Associated with Later AD/ADRD RiskR01AG049789 · NIA · DUKE UNIVERSITY · PI AHMAD R. HARIRI, TERRIE E MOFFITT · 2015 to 2026
$10.6M
Is mental disorder a preventable cause of age-related disease? The Dunedin Study.R01AG032282 · NIA · DUKE UNIVERSITY · PI CASPI, AVSHALOM, MOFFITT, TERRIE E · 2009 to 2025
$9.5M
Comprehensive portrait of long-term cannabis users: Are they ready for old age?R01AG069939 · NIA · DUKE UNIVERSITY · PI MOFFITT, TERRIE E · 2021 to 2024
$1.3M
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NIA NIH HHS R01 AG032282NIA NIH HHS R01 AG049789NIA NIH HHS R01 AG054076NIA NIH HHS R01 AG069939NIA NIH HHS U01 AG024904
6 · The paper itself

Abstract

Biological aging is the correlated decline of multi-organ system integrity central to the etiology of many age-related diseases. A novel epigenetic measure of biological aging, DunedinPACE, is associated with cognitive dysfunction, incident dementia, and mortality. Here, we tested for associations between DunedinPACE and structural MRI phenotypes in three datasets spanning midlife to advanced age: the Dunedin Study (age=45 years), the Framingham Heart Study Offspring Cohort (mean age=63 years), and the Alzheimer's Disease Neuroimaging Initiative (mean age=75 years). We also tested four additional epigenetic measures of aging: the Horvath clock, the Hannum clock, PhenoAge, and GrimAge. Across all datasets (total N observations=3,380; total N individuals=2,322), faster DunedinPACE was associated with lower total brain volume, lower hippocampal volume, and thinner cortex. In two datasets, faster DunedinPACE was associated with greater burden of white matter hyperintensities. Across all measures, DunedinPACE and GrimAge had the strongest and most consistent associations with brain phenotypes. Our findings suggest that single timepoint measures of multi-organ decline such as DunedinPACE could be useful for gauging nervous system health.

Identifiers

PMID37732266
PMCPMC10508789
OpenAlexW4386532603

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.