Evidence map›Paper›PMID 37732261›Full record

ArticlemedRxiv : the preprint server for health sciences2023

Racial and Ethnic Differences in the Association between Depressive Symptoms and Cognitive Outcomes in Older Adults: Findings from KHANDLE and STAR.

Marcia P Jimenez, Emma L Gause, Eleanor Hayes-Larson, Emily P Morris, Evan Fletcher, Jennifer Manly, Paola Gilsanz, Yenee Soh, Maria Corrada, Rachel A Whitmer and 1 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Marcia P JimenezDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Emma L GauseCenter for Climate and Health, Boston University School of Public Health, Boston, MA, USA.
Eleanor Hayes-LarsonDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, CA, USA.
Emily P MorrisDepartment of Psychology, University of Michigan, Ann Arbor, MI, USA.
Evan FletcherDepartment of Neurology, University of California, Davis, CA, USA.
Jennifer ManlyDepartment of Neurology, Columbia University, New York, NY, USA.
Paola GilsanzDivision of Research, Kaiser Permanente, Oakland, CA, USA.
Yenee SohDivision of Research, Kaiser Permanente, Oakland, CA, USA.
Maria CorradaDepartment of Epidemiology, University of California Irvine School of Medicine, Irvine, CA, USA.
Rachel A WhitmerDepartment of Public Health Sciences and Neurology, University of California Davis School of Medicine, Davis, CA, USA.
M Maria GlymourDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
Boston University · USKaiser Permanente · USUniversity of California, Davis · USColumbia University · USUCLA Health · USUniversity of California, Irvine · USUniversity of Michigan · US

Funding

UC Davis Alzheimer's Disease Research CenterP30AG072972 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Charles DeCarli, Rachel A Whitmer · 2021 to 2026
$25.2M
Lifecourse health, cerebral pathology and ethnic disparities in dementia (KHANDLE Study)R01AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI GILSANZ, PAOLA, GLYMOUR, MEDELLENA MARIA · 2021 to 2025
$18.0M
Early Vascular Contributions to Dementia Risk in African-AmericansRF1AG050782 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WHITMER, RACHEL A · 2017 to 2017
$3.8M
Neurodegenerative diseases and the role of green space: A deep learning assessmentR00AG066949 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI PESCADOR JIMENEZ, MARCIA IXCHEL · 2022 to 2024
$738k
NIA NIH HHS P30 AG072972NIA NIH HHS R00 AG066949NIA NIH HHS R01 AG052132NIA NIH HHS RF1 AG050782
6 · The paper itself

Abstract

introductionDepressive symptoms are associated with higher risk of dementia but how they impact cognition in diverse populations is unclear.

methodsAsian, Black, LatinX, or White participants (n=2,227) in the Kaiser Healthy Aging and Diverse Life Experiences (age 65+) and the Study of Healthy Aging in African Americans (age 50+) underwent up to three waves of cognitive assessments over four years. Multilevel models stratified by race/ethnicity were used to examine whether depressive symptoms were associated with cognition or cognitive decline and whether associations differed by race/ethnicity.

resultsHigher depressive symptoms were associated with lower baseline verbal episodic memory scores (-0.06, 95%CI: -0.12, -0.01; -0.15, 95%CI: -0.25, -0.04), and faster decline annually in semantic memory (-0.04, 95%CI: -0.07, -0.01; -0.10, 95%CI: -0.15, -0.05) for Black and LatinX participants. Depressive symptoms were associated with lower baseline but not decline in executive function. DISCUSSION: Depressive symptoms were associated with worse cognitive domains, with some evidence of heterogeneity across racial/ethnic groups.

Indexed as

Alzheimer’s DiseaseCognitive FunctionDepressive SymptomsLongitudinal DataMental HealthRace and Ethnicity

Identifiers

PMID37732261
PMCPMC10508807
OpenAlexW4386532573

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.