Evidence map›Paper›PMID 37732235›Full record

ArticlebioRxiv : the preprint server for biology2023

Efficient ultrasound-mediated drug delivery to orthotopic liver tumors - Direct comparison of doxorubicin-loaded nanobubbles and microbubbles.

Pinunta Nittayacharn, Eric Abenojar, Michaela Cooley, Felipe Berg, Claire Counil, Amin Jafari Sojahrood, Muhammad Saad Khan, Celina Yang, Elizabeth Berndl, Marcin Golczak and 2 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 3 countries.

Pinunta NittayacharnDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Eric AbenojarDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Michaela CooleyDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Felipe BergDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
Claire CounilDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Amin Jafari SojahroodDepartment of Physics, Toronto Metropolitan University, Toronto, Canada.
Muhammad Saad KhanDepartment of Physics, Toronto Metropolitan University, Toronto, Canada.
Celina YangDepartment of Physics, Toronto Metropolitan University, Toronto, Canada.
Elizabeth BerndlDepartment of Physics, Toronto Metropolitan University, Toronto, Canada.
Marcin GolczakDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH, USA.
Michael C KoliosDepartment of Physics, Toronto Metropolitan University, Toronto, Canada.
Agata A ExnerDepartment of Radiology, Case Western Reserve University, Cleveland, OH, USA.
Case Western Reserve University · USToronto Metropolitan University · CAHospital Israelita Albert Einstein · BR

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Drug-Loaded Nanobubbles for Ultrasound Enhanced Delivery to Colon Cancer Liver MetastasisR01EB028144 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI EXNER, AGATA A · 2019 to 2023
$2.3M
NEI NIH HHS P30 EY011373NIBIB NIH HHS R01 EB028144NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

Liver metastasis is a major obstacle in treating aggressive cancers, and current therapeutic options often prove insufficient. To overcome these challenges, there has been growing interest in ultrasound-mediated drug delivery using lipid-shelled microbubbles (MBs) and nanobubbles (NBs) as promising strategies for enhancing drug delivery to tumors. Our previous work demonstrated the potential of Doxorubicin-loaded C

Indexed as

cavitationDoxorubicindrug deliveryliver metastasismicrobubblesnanobubblesorthotopic tumorsonoporationultrasound-mediated drug delivery

Identifiers

PMID37732235
PMCPMC10508722
OpenAlexW4386446427

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.