Evidence map›Paper›PMID 37732222›Full record

ArticlebioRxiv : the preprint server for biology2023

Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1.

Hannah L Itell, Daryl Humes, Nell E Baumgarten, Julie Overbaugh

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hannah L ItellMolecular and Cellular Biology PhD Program, University of Washington, Seattle, WA, 98109, USA.
Daryl HumesDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Nell E BaumgartenDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Julie OverbaughDivision of Human Biology, Fred Hutchinson Cancer Center, Seattle, WA, 98109, USA.
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Innate immune determinants of HIV rebound and persistenceR01HD103571 · NICHD · FRED HUTCHINSON CANCER RESEARCH CENTER · PI JULIE M. OVERBAUGH · 2020 to 2026
$6.7M
Cell-intrinsic effectors of the antiviral interferon response against HIV in primary human samplesF31AI165168 · NIAID · FRED HUTCHINSON CANCER CENTER · PI ITELL, HANNAH · 2022 to 2023
$61k
NIAID NIH HHS F31 AI165168NICHD NIH HHS R01 HD103571NIGMS NIH HHS T32 GM007270
6 · The paper itself

Abstract

HIV-1 infection involves a selection bottleneck that leads to transmission of one or a few HIV variants, which nearly always use CCR5 as the coreceptor (R5 viruses) for viral entry as opposed to CXCR4 (X4 viruses). The host properties that drive this selection are not well understood and may hold keys to factors that govern HIV susceptibility. In this report, we identified SLC35A2, a transporter of UDP-galactose, as a candidate X4-specific restriction factor in CRISPR-knockout screens in primary target CD4

Identifiers

PMID37732222
PMCPMC10508750
OpenAlexW4386480509

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.