Evidence map›Paper›PMID 37732183›Full record

ArticlebioRxiv : the preprint server for biology2025

Human deleterious mutation rate slows adaptation and implies high fitness variance.

Joseph Matheson, Ulises Hernández, Jason Bertram, Joanna Masel

Open access · greenAbstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Joseph MathesonDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, 85721, USA.ORCID 0000-0001-5083-8248
Ulises HernándezDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, 85721, USA.
Jason BertramDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, 85721, USA.ORCID 0000-0001-5374-6912
Joanna MaselDepartment of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, 85721, USA.ORCID 0000-0002-7398-2127
University of Arizona · USWestern University · CA

Funding

Computational and Mathematical Modeling of Biomedical SystemsT32GM084905 · NIGMS · UNIVERSITY OF ARIZONA · PI SECOMB, TIMOTHY W. · 2009 to 2018
$2.2M
NIGMS NIH HHS T32 GM084905
6 · The paper itself

Abstract

Each new human has an expected

Indexed as

background selectionbinary indexed treechromosome numberMuller’s ratchetmutational meltdownmutation loadOhta’s ratchet

Identifiers

PMID37732183
PMCPMC10508744
OpenAlexW4386441809

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.