ArticleArchives of medical science : AMS2023
CD39 molecule: a negative regulator expressed on T cells in patients with lung adenocarcinoma.
Article in Archives of medical science : AMS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- CD39 Expression in Peripheral CD4+ T Lymphocytes Is Associated With Disease Activity in Patients With Systemic Lupus Erythematosus.Journal of immunology research · 2026Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The function of cytotoxic cells may be impacted by CD39 expression on CD8-positive T lymphocytes, leading to an imbalance in tumor immunity. Methods: We analyzed the correlation between the expression of CD39 on CD8-positive T lymphocytes and clinical information in 203 patients with lung adenocarcinoma. Results: The expression of CD39 on CD8-positive T lymphocytes was related to T stage, lymph node metastasis and distant metastasis. Furthermore, the CD39 expression reduced the secretion of antitumor cytokines, promoted PD-1 expression and decreased CD28 expression on CD8-positive T lymphocytes. Conclusions: This research demonstrated the potential value of CD39 on CD8-positive T lymphocytes as a negative regulator in cancer immunotherapy.
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