ArticleArchives of medical science : AMS2023
Reduction of lymphocyte count at early stage elevates severity and death risk of COVID-19 patients: a hospital-based case-cohort study.
Article in Archives of medical science : AMS, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis.The American journal of emergency medicine · 2021Pooled it
- Prognostic factors for severity and mortality in patients infected with COVID-19: A systematic review.PloS one · 2020Pooled it
- Pooled it
- Serum desmosine served as a biomarker for severity and prognosis in COVID-19 patients.BMC pulmonary medicine · 2026Article
- Sex-Specific Signatures of Circulating Protein and Cellular Host Responses Predicting COVID-19 Severity.Medical sciences (Basel, Switzerland) · 2026Article
- Serum syndecan-1 is related to severity and prognosis of COVID-19 patients: a perspective cohort study.BMC pulmonary medicine · 2025Article
- Factors influencing the risk of cardiovascular complications following COVID-19 - clinical implications. The LATE-COVID study.Archives of medical science : AMS · 2025Article
- The systemic inflammation response index (SIRI) is associated with all-cause and cardiovascular mortality in maintenance hemodialysis patients.Archives of medical science : AMS · 2025Article
- A single-center, retrospective study of hospitalized patients with lower respiratory tract infections: clinical assessment of metagenomic next-generation sequencing and identification of risk factors in patients.Respiratory research · 2024Article
- Advancing insights in critical COVID-19: unraveling lymphopenia through propensity score matching - Findings from the Multicenter LYMPH-COVID Study.Critical care science · 2024Article
- Elevation of truncated (48 kDa) form of unconventional myosin 1C in blood serum correlates with severe Covid-19.Journal of immunological methods · 2023Article
- Exhaustion and over-activation of immune cells in COVID-19: Challenges and therapeutic opportunities.Clinical immunology (Orlando, Fla.) · 2022Review
- Severity and Mortality Predictors of COVID-19 Patients with Thrombotic Events-Evidence from theVaccines · 2022Article
- Serum IL-27 predicts the severity and prognosis in patients with community-acquired pneumonia: a prospective cohort study.International journal of medical sciences · 2022Article
- Prospects of animal models and their application in studies on adaptive immunity to SARS-CoV-2.Frontiers in immunology · 2022Review
- Clinical frailty score as an independent predictor of outcome in COVID-19 hospitalised patients.European geriatric medicine · 2021Article
- Renal dysfunction and prognosis of COVID-19 patients: a hospital-based retrospective cohort study.BMC infectious diseases · 2021Article
- Associations of Serum Resistin With the Severity and Prognosis in Patients With Community-Acquired Pneumonia.Frontiers in immunology · 2021Article
- Associations of Serum S100A12 With Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Prospective Cohort Study.Frontiers in immunology · 2021Article
- The Associations of Serum IL-37 With the Severity and Prognosis in Patients With Community-Acquired Pneumonia: A Retrospective Cohort Study.Frontiers in immunology · 2021Article
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Abstract
Introduction: Several reports have noted that severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) induced lymphopenia in coronavirus disease 2019 (COVID-19) patients. However, the clinical significance of lymphopenia remains unclear. The objective of this study was to analyze the association between lymphopenia at an early stage and the prognosis of COVID-19 patients. Material and methods: All 192 hospitalized patients with COVID-19 were enrolled. Demographic data and clinical characteristics were collected and patient's prognosis was followed up. Results: On admission, 84 (43.8%) patients suffered from lymphopenia among COVID-19 patients. The count and percentage of lymphocytes on admission were lower among patients over 70 years old than those of younger patients. Multivariate logistic regression revealed that older age was a risk factor of lymphopenia. Of interest, chest CT score, a key marker of lung injury, was increased among COVID-19 patients with lymphopenia. By contrast, PaCO Conclusions: Older COVID-19 patients are more susceptible to lymphopenia. Multiple organ injuries were more serious in COVID-19 patients with lymphopenia. Lymphopenia at an early stage aggravates the severity and elevates the death risk of COVID-19 patients.
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