ArticleFrontiers in neurology2023
Reversible splenial lesion syndrome in children: a retrospective study of 130 cases.
Article in Frontiers in neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS): A case report and review of the literature.Radiology case reports · 2026Article
- Paroxysmal Speech Arrest With Resolving Splenial and Symmetric White Matter Lesions in a Child: A Case Report.Cureus · 2026Article
- Article
- A case of recurrent RESLES type I: analysis of pathogenic factors and delayed imaging manifestations.Frontiers in medicine · 2026Article
- Some novel causes and clinical characteristics of reversible splenial lesion syndrome- found in children.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Cytotoxic Lesions of the Corpus Callosum (CLOCC) in Siblings: A Case Report.Current medical imaging · 2025Article
- Clinical Variability of Pediatric MERS: Insights from a Retrospective Observational Study.Journal of clinical medicine · 2025Article
- Cytotoxic Lesions of the Corpus Callosum (CLOCCs) in a Patient with Epstein-Barr Infection: A Case Report and Literature Review.Brain sciences · 2025Article
- Callosal Injuries in Cytomegalovirus Fetopathy: A Neurosonographic Study.Fetal diagnosis and therapy · 2025Article
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Authors and funding
7 authors.
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Abstract
Background: Reversible splenial lesion syndrome (RESLES) is a new clinico-radiological syndrome. We retrospectively analyzed the clinical features of 130 children with RESLES in China, which is the largest case series available in the literature. Methods: The clinical data of children diagnosed as RESLES in Jiangxi Provincial Children's Hospital between 2017 and 2023 were retrospectively analyzed. The 130 cases were divided into two groups: ≤ 3 years old group (group A) ( Results: The vast majority of patients (127/130 cases, 97.7%) had prodromal symptoms of infection. Preceding infections of the gastrointestinal tract were statistically more significant in group A (60/83, 72.3%) than in group B (11/47, 23.4%) ( Conclusion: Infection was the most common cause of RESLES. Infections of the gastrointestinal tract are common in ≤ 3 years old children, while infections of the respiratory tract are common in >3 years old children. Younger patients are more likely to develop convulsions, and older children were more likely to have symptoms with disturbance of consciousness and headache/dizziness. RESLES has characteristic MRI manifestations and a good prognosis.
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