Evidence map›Paper›PMID 37731767›Full record

ArticleFrontiers in bioengineering and biotechnology2023

Quantification and modeling of macroparticle-induced mechanical stress for varying shake flask cultivation conditions.

Marcel Schrader, Kathrin Schrinner, Laura Polomsky, Dimitri Ivanov, Ingo Kampen, Carsten Schilde, Rainer Krull, Arno Kwade

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Marcel Schrader *Institute for Particle Technology, Technische Universität Braunschweig, Braunschweig, Germany.
Kathrin SchrinnerCenter of Pharmaceutical Engineering, Technische Universität Braunschweig, Braunschweig, Germany.
Laura PolomskyInstitute for Particle Technology, Technische Universität Braunschweig, Braunschweig, Germany.
Dimitri IvanovInstitute for Particle Technology, Technische Universität Braunschweig, Braunschweig, Germany.
Ingo KampenInstitute for Particle Technology, Technische Universität Braunschweig, Braunschweig, Germany.
Carsten SchildeInstitute for Particle Technology, Technische Universität Braunschweig, Braunschweig, Germany.
Rainer KrullCenter of Pharmaceutical Engineering, Technische Universität Braunschweig, Braunschweig, Germany.
Arno KwadeInstitute for Particle Technology, Technische Universität Braunschweig, Braunschweig, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In biotechnological processes, filamentous microorganisms are known for their broad product spectrum and complex cellular morphology. Product formation and cellular morphology are often closely linked, requiring a well-defined level of mechanical stress to achieve high product concentrations. Macroparticles were added to shake flask cultures of the filamentous actinomycete

Indexed as

CFD-DEM simulationfilamentous microorganismmacroparticle-enhanced cultivationmechanical stressrebeccamycinshake flask

Identifiers

PMID37731767
PMCPMC10507416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.