Evidence map›Paper›PMID 37731626›Full record

ReviewStem cells international2023

The Functions and Mechanisms of Tendon Stem/Progenitor Cells in Tendon Healing.

Jingwei Lu, Hui Chen, Kexin Lyu, Li Jiang, Yixuan Chen, Longhai Long, Xiaoqiang Wang, Houyin Shi, Sen Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
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  8. Article
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  15. Epigenetic mechanisms in stem cell therapies for achilles tendinopathy.Frontiers in cell and developmental biology · 2025
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Optimizing tendon repair and regeneration: how does theFrontiers in bioengineering and biotechnology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jingwei LuSchool of Physical Education, Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0003-1556-0927
Hui ChenGeriatric Department, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0009-0009-9196-2072
Kexin LyuSchool of Physical Education, Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0002-6008-5371
Li JiangSchool of Physical Education, Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0001-5033-5712
Yixuan ChenSchool of Physical Education, Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0009-0008-2148-0847
Longhai LongSpinal Surgery Department, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0001-7061-8103
Xiaoqiang WangSpinal Surgery Department, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0002-1441-0460
Houyin ShiSpinal Surgery Department, The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0009-0006-4659-2509
Sen LiDivision of Spine Surgery, Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.ORCID https://orcid.org/0000-0002-4819-097X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tendon injury is one of the prevalent disorders of the musculoskeletal system in orthopedics and is characterized by pain and limitation of joint function. Due to the difficulty of spontaneous tendon healing, and the scar tissue and low mechanical properties that usually develops after healing. Therefore, the healing of tendon injury remains a clinical challenge. Although there are a multitude of approaches to treating tendon injury, the therapeutic effects have not been satisfactory to date. Recent studies have shown that stem cell therapy has a facilitative effect on tendon healing. In particular, tendon stem/progenitor cells (TSPCs), a type of stem cell from tendon tissue, play an important role not only in tendon development and tendon homeostasis, but also in tendon healing. Compared to other stem cells, TSPCs have the potential to spontaneously differentiate into tenocytes and express higher levels of tendon-related genes. TSPCs promote tendon healing by three mechanisms: modulating the inflammatory response, promoting tenocyte proliferation, and accelerating collagen production and balancing extracellular matrix remodeling. However, current investigations have shown that TSPCs also have a negative effect on tendon healing. For example, misdifferentiation of TSPCs leads to a "failed healing response," which in turn leads to the development of chronic tendon injury (tendinopathy). The focus of this paper is to describe the characteristics of TSPCs and tenocytes, to demonstrate the roles of TSPCs in tendon healing, while discussing the approaches used to culture and differentiate TSPCs. In addition, the limitations of TSPCs in clinical application and their potential therapeutic strategies are elucidated.

Identifiers

PMID37731626
PMCPMC10509002

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.