Evidence map›Paper›PMID 37731585›Full record

ArticlemLife2022

Distinct gut microbiota and health outcomes in asymptomatic infection, viral nucleic acid test re-positive, and convalescent COVID-19 cases.

Ruqin Lin, Mingzhong Xiao, Shanshan Cao, Yu Sun, Linhua Zhao, Xiaoxiao Mao, Peng Chen, Xiaolin Tong, Zheyuan Ou, Hui Zhu and 5 more

Abstract read
In one paragraph

Article in mLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Frontiers in immunology · 2026
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruqin LinGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences South China Agricultural University Guangzhou China.
Mingzhong XiaoHepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan China.
Shanshan CaoState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science Chinese Academy of Sciences Wuhan China.
Yu SunGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences South China Agricultural University Guangzhou China.
Linhua ZhaoDepartment of Endocrinology Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing China.
Xiaoxiao MaoGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences South China Agricultural University Guangzhou China.
Peng ChenHepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan China.
Xiaolin TongDepartment of Endocrinology Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing China.
Zheyuan OuGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences South China Agricultural University Guangzhou China.
Hui ZhuHepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan China.
Dong MenState Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science Chinese Academy of Sciences Wuhan China.
Xiaodong LiHepatic Disease Institute, Hubei Key Laboratory of Theoretical and Applied Research of Liver and Kidney in Traditional Chinese Medicine Hubei Provincial Hospital of Traditional Chinese Medicine Wuhan China.
Yiqun DengGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences South China Agricultural University Guangzhou China.
Xian-En ZhangNational Laboratory of Biomacromolecules, Institute of Biophysics Chinese Academy of Sciences Beijing China.
Jikai WenGuangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences South China Agricultural University Guangzhou China.ORCID 0000-0002-4010-4416

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gut microbiota composition is suggested to associate with coronavirus disease 2019 (COVID-19) severity, but the impact of gut microbiota on health outcomes is largely unclear. We recruited 81 individuals from Wuhan, China, including 13 asymptomatic infection cases (Group A), 24 COVID-19 convalescents with adverse outcomes (Group C), 31 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) re-positive cases (Group D), and 13 non-COVID-19 healthy controls (Group H). The microbial features of Groups A and D were similar and exhibited higher gut microbial diversity and more abundant short-chain fatty acid (SCFA)-producing species than Group C. Group C was enriched with opportunistic pathogens and virulence factors related to adhesion and toxin production. The abundance of SCFA-producing species was negatively correlated, while

Indexed as

COVID‐19gut microbiotahealth outcomesre‐positiveSARS‐CoV‐2

Identifiers

PMID37731585
PMCPMC9349603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.