Evidence map›Paper›PMID 37731516›Full record

ArticleVaccine: X2023

Longitudinal long COVID symptoms in Japanese patients after COVID-19 vaccinations.

Kensuke Nakagawara, Atsuho Morita, Ho Namkoong, Hideki Terai, Shotaro Chubachi, Takanori Asakura, Hiromu Tanaka, Fumimaro Ito, Emiko Matsuyama, Masanori Kaji and 33 more

Abstract read
In one paragraph

Article in Vaccine: X, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Japanese nationwide survey to track the impact of long COVID over 3 years.Environmental health and preventive medicine · 2025
    Article
  5. Translating insights into therapies for Long Covid.Science translational medicine · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

43 authors.

Kensuke NakagawaraDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Atsuho MoritaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ho NamkoongDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Hideki TeraiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Shotaro ChubachiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Takanori AsakuraDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hiromu TanakaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Fumimaro ItoDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Emiko MatsuyamaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Masanori KajiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ayaka SaitoDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hatsuyo TakaokaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Masahiko OkadaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Keeya SunataDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Mayuko WataseDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Kazuma YagiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Keiko OhginoDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Jun MiyataDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Hirofumi KamataDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Ichiro KawadaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Keigo KobayashiDepartment of Internal Medicine, Sano Kosei General Hospital, Tochigi, Japan.
Toshiyuki HiranoDepartment of Internal Medicine, Sano Kosei General Hospital, Tochigi, Japan.
Takashi InoueDepartment of Internal Medicine, Sano Kosei General Hospital, Tochigi, Japan.
Junko KagyoDepartment of Internal Medicine, Keiyu Hospital, Kanagawa, Japan.
Tetsuya ShiomiDepartment of Internal Medicine, Keiyu Hospital, Kanagawa, Japan.
Kengo OtsukaDepartment of Internal Medicine, Nihon Koukan Hospital, Kanagawa, Japan.
Naoki MiyaoDepartment of Internal Medicine, Nihon Koukan Hospital, Kanagawa, Japan.
Toshio OdaniDepartment of Rheumatology, National Hospital Organization Hokkaido Medical Center, Hokkaido, Japan.
Rie BabaPulmonary Division, Department Internal Medicine, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
Daisuke AraiPulmonary Division, Department Internal Medicine, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
Ichiro NakachiPulmonary Division, Department Internal Medicine, Saiseikai Utsunomiya Hospital, Tochigi, Japan.
Soichiro UedaDepartment of Internal Medicine, Saitama Medical Center, Saitama, Japan.
Yohei FunatsuDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tokyo, Japan.
Hidefumi KohDivision of Pulmonary Medicine, Department of Internal Medicine, Tachikawa Hospital, Tokyo, Japan.
Kota IshiokaDepartment of Pulmonary Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Saeko TakahashiDepartment of Pulmonary Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Morio NakamuraDepartment of Pulmonary Medicine, Tokyo Saiseikai Central Hospital, Tokyo, Japan.
Toshiro SatoDepartment of Organoid Medicine, Keio University School of Medicine, Tokyo, Japan.
Naoki HasegawaDepartment of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
Yuko KitagawaDepartment of Surgery, Keio University School of Medicine, Tokyo, Japan.
Takanori KanaiDivision of Gastroenterology and Hepatology Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
Makoto IshiiDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.
Koichi FukunagaDivision of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We conducted a subgroup analysis of a study on the long-term effects of COVID-19 (long COVID) in Japan to assess the effect of vaccination on long COVID symptoms. We assessed the clinical course of 111 patients with long COVID at the time of vaccination. The follow-up period was one year from the onset of COVID-19 or until the administration of the third vaccine dose. Of the 111 patients, 15 (13.5%) reported improvement, four (3.6%) reported deterioration, and 92 (82.9%) reported no change in their long COVID symptoms after vaccination. The most common long COVID symptoms before vaccination were alopecia, dyspnea, muscle weakness, fatigue, and headache among participants whose symptoms improved. Reduced dyspnea and alopecia were the most frequently reported improvements in symptoms after vaccination. Some symptoms persisted, including sleep disturbance, myalgia, and hypersensitivity. Vaccination did not appear to have a clinically important effect on patients with long COVID symptoms.

Indexed as

post-COVID-19 syndromeSARS-CoV-2 infectionVaccination

Identifiers

PMID37731516
PMCPMC10507639

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.