Evidence map›Paper›PMID 37731151›Full record

ReviewLa Radiologia medica2024

Reirradiation of head and neck squamous cell carcinomas: a pragmatic approach-part I: prognostic factors and indications to treatment.

Daniela Alterio, Mattia Zaffaroni, Paolo Bossi, Francesco Dionisi, Olgun Elicin, Andrea Falzone, Annamaria Ferrari, Barbara Alicja Jereczek-Fossa, Giuseppe Sanguineti, Petr Szturz and 2 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in La Radiologia medica, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Observational
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniela AlterioDivision of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.
Mattia ZaffaroniDivision of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy. mattia.zaffaroni@ieo.it.ORCID http://orcid.org/0000-0003-4655-4634
Paolo BossiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.
Francesco DionisiRadiotherapy Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Olgun ElicinDepartment of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Andrea FalzoneUnità Operativa Multizonale di Radiologia Ospedale di Rovereto e Arco, Azienda Sanitaria per i Servizi Provinciali di Trento, Trento, Italy.
Annamaria FerrariDivision of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.
Barbara Alicja Jereczek-FossaDivision of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.ORCID http://orcid.org/0000-0001-8151-3673
Giuseppe SanguinetiRadiotherapy Unit, IRCCS Regina Elena National Cancer Institute, Rome, Italy.
Petr SzturzDepartment of Oncology, University of Lausanne (UNIL) and Lausanne University Hospital (CHUV), Lausanne, Switzerland.
Stefania VolpeDivision of Radiation Oncology, IEO European Institute of Oncology IRCCS, Milan, Italy.
Melissa ScriccioloRadiation Therapy Unit, Ospedale dell'Angelo, Venice, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionReirradiation (reRT) of locally recurrent/second primary tumors of the head and neck region is a potentially curative treatment for patients not candidate to salvage surgery. Aim of the present study is to summarize available literature on both prognostic factors and indications to curative reRT in this clinical setting. MATERIALS AND

methodsA narrative review of the literature was performed on two topics: (1) patients' selection according to prognostic factors and (2) dosimetric feasibility of reRT. Postoperative reRT and palliative intent treatments were out of the scope of this work.

resultsPatient-tumor and treatment-related prognostic factors were analyzed, together with dosimetric parameters concerning target volume and organs at risk. Based on available evidence, a stepwise approach has been proposed aiming to provide a useful tool to identify suitable candidates for curative reRT in clinical practice. This was then applied to two clinical cases, proposed at the end of this work.

conclusionA second course of RT in head and neck recurrence/second primary tumors is a personalized approach that can be offered to selected patients only in centers with expertise and dedicated equipment following a multidisciplinary team discussion.

Indexed as

Head and Neck NeoplasmsRe-IrradiationHumansNeoplasm Recurrence, LocalPrognosisSalvage TherapySquamous Cell Carcinoma of Head and NeckHead and neck cancerPrognostic factorsReirradiationSquamous cell carcinomaTreatment

Identifiers

PMID37731151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.