Evidence map›Paper›PMID 37731043›Full record

ArticleThe Journal of antibiotics2023

Sheptide A: an antimalarial cyclic pentapeptide from a fungal strain in the Herpotrichiellaceae.

Robert A Shepherd, Cody E Earp, Kristof B Cank, Huzefa A Raja, Joanna Burdette, Steven P Maher, Adriana A Marin, Anthony A Ruberto, Sarah Lee Mai, Blaise A Darveaux and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of antibiotics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Robert A ShepherdDepartment of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Cody E EarpDepartment of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Kristof B CankDepartment of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.
Huzefa A RajaDepartment of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA.ORCID 0000-0002-0824-9463
Joanna BurdetteDepartment of Pharmaceutical Sciences, University of Illinois Chicago, Chicago, IL, USA.ORCID 0000-0002-7271-6847
Steven P MaherCenter for Tropical & Emerging Global Diseases, University of Georgia, Athens, GA, USA.
Adriana A MarinCenter for Tropical & Emerging Global Diseases, University of Georgia, Athens, GA, USA.
Anthony A RubertoCenter for Tropical & Emerging Global Diseases, University of Georgia, Athens, GA, USA.ORCID 0000-0002-3215-9484
Sarah Lee MaiCenter for Tropical & Emerging Global Diseases, University of Georgia, Athens, GA, USA.
Blaise A DarveauxMycosynthetix, Inc., Hillsborough, NC, USA.
Dennis E KyleCenter for Tropical & Emerging Global Diseases, University of Georgia, Athens, GA, USA.
Cedric J PearceMycosynthetix, Inc., Hillsborough, NC, USA.ORCID 0000-0002-0212-1127
Nicholas H OberliesDepartment of Chemistry & Biochemistry, University of North Carolina at Greensboro, Greensboro, NC, USA. n_oberli@uncg.edu.ORCID 0000-0002-0354-8464

Funding

Project 3:Isolation Chemistry of Filamentous Fungi and Biological EvaluationP01CA125066 · NCI · OHIO STATE UNIVERSITY · PI Joanna E Burdette · 2007 to 2026
$27.2M
Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
Anti-Malarial Drug Leads from FungiR21AI163960 · NIAID · UNIVERSITY OF NORTH CAROLINA GREENSBORO · PI OBERLIES, NICHOLAS H. · 2021 to 2022
$399k
NCI NIH HHS P01 CA125066NIAID NIH HHS R21 AI163960NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

As part of ongoing efforts to isolate biologically active fungal metabolites, a cyclic pentapeptide, sheptide A (1), was discovered from strain MSX53339 (Herpotrichiellaceae). The structure and sequence of 1 were determined primarily by analysis of 2D NMR and HRMS/MS data, while the absolute configuration was assigned using a modified version of Marfey's method. In an in vitro assay for antimalarial potency, 1 displayed a pEC

Indexed as

AntimalarialsAscomycotaMalariaHumansPlant ExtractsPlasmodium falciparumAntimalarialsPlant Extracts

Identifiers

PMID37731043
PMCPMC10602849

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.