ArticleNature2023
The β
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07187284 (Evaluating Endervascular Denervation), which is not on this map. Cited by 190 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 1 pooled it
46.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT07187284 phase1 / phase2not yet recruitingnot on this mapstarted 2025, after this paper: background citation
Evaluating Endervascular Denervation (EDN) Combined With Transarterial Intervention (TACE/HAIC) and Second-Line Immune-Targeted Therapy in Locally Advanced Hepatocellular Carcinoma (HCC) With Portal Vein Tumor Thrombosis After Progression on First-Line Systemic Therapy: A Prospective, Multicenter, Randomized Controlled Study
Who cites it
190 citing papers in PubMed, 1 synthesis or guideline pooled it, 208 citations in OpenAlex.
- The Efficacy and Safety of Beta-blockers and Immune Checkpoint Inhibitors in Patients with Cancer: A Systematic Review and Meta-analysis.Targeted oncology · 2025Pooled it
- Effect of the mitophagy inducer urolithin A on age-related immune decline: a randomized, placebo-controlled trial.Nature aging · 2025Trial
- Neuro-immune interactions in tumors, immune-related disorders, and infections.Signal transduction and targeted therapy · 2026Review
- Chronic stress and myeloid immunosuppression in cancer: A neuroimmune link to behavioral dysfunction.Brain, behavior, & immunity - health · 2026Review
- A two-hit mechanism triggers autoimmune hair loss.Nature · 2026Article
- Neural-tumor interactions: bidirectional regulatory mechanisms and nervous system-targeted tumor therapeutic strategies.Biomarker research · 2026Review
- Immune-pressure redistribution in resistance to PD-1/PD-L1 blockade: mechanisms, biomarkers, and therapeutic design.Molecular cancer · 2026Review
- Decoding neuro-tumor interactions in pancreatic cancer: mechanisms, immunosuppressive networks and therapeutic opportunities.Molecular biomedicine · 2026Review
- Neuroscience in prostate cancer.Prostate cancer and prostatic diseases · 2026Review
- Integrative bioinformatic and experimental analysis reveals prognostic and immunological roles of psychological stress-related genes in skin cutaneous melanoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Targeting the nervous system: Mechanistic insights into neuro-tumor communication and therapeutic opportunities.Acta pharmaceutica Sinica. B · 2026Review
- The tumor microenvironment in pancreatic cancer: from composition to therapeutic targeting.Biochemical Society transactions · 2026Review
- Neural regulation of cancer: from microenvironmental hijacking to systemic circuit co-option.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- Long-term major histocompatibility complex class I suppression in astronauts and clinical implications.Communications biology · 2026Review
- Depression remodels tumor microenvironment to drive tumor progression: Bio-behavioural signalling pathways and clinical interventions.Journal of advanced research · 2026Review
- Pancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart.The Journal of physiology · 2026Article
- Neural regulation of tumor immunity: emerging opportunities to enhance cancer immunotherapy.Experimental & molecular medicine · 2026Review
- Low-intensity pulsed ultrasound-mediated nose-to-brain co-delivery of β-blockers and aPD-L1 enhances glioblastoma immunotherapy.Nature communications · 2026Article
- Review
- Human GPR174 deficiency drives polyclonal lymphoproliferative disease via defects in T cell function.medRxiv : the preprint server for health sciences · 2026Article
130 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 3 institutions in 1 country.
Anna-Maria GlobigNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-5236-7459
Steven ZhaoNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-8102-8368
Jessica RoginskyNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-1174-8423
Vivien I MaltezLymphocyte Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.
Juan GuizaDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3843-5048
Natalia Avina-OchoaNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-5804-8766
Maximilian HeegDivision of Biological Sciences, Department of Molecular Biology, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-9594-1377
Filipe Araujo HoffmannNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Omkar ChaudharySection of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.
Jiawei WangDepartment of Psychiatry, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2627-4897
Gokhan SenturkGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-7005-9644
Dan ChenNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Carolyn O'ConnorNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA.
Samuel PfaffGene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-2142-166X
Ronald N GermainLymphocyte Biology Section, Laboratory of Immune System Biology, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0003-1495-9143
Kurt A SchalperDepartment of Pathology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-5692-4833
Brinda EmuSection of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.
Susan M KaechNOMIS Center for Immunobiology and Microbial Pathogenesis, Salk Institute for Biological Studies, La Jolla, CA, USA. skaech@salk.edu.ORCID 0000-0003-1674-1420
Salk Institute for Biological Studies · USYale University · USUniversity of California San Diego · US
Funding
VIRAL MALIGNANCYP30CA023100 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jesse Nodora · 1985 to 2026
$124.9MYale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MViral Vector Core (VVC)P30CA014195 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI Reuben Shaw · 1985 to 2026
$82.8MYale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung CancerP50CA196530 · NCI · YALE UNIVERSITY · PI Kurt A Schalper · 2015 to 2026
$31.1M(PQ5) Mitochondrial Heterogeneity in Melanoma Tumor and Immune ResponsesR01CA216101 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GERALD SHADEL · 2018 to 2026
$5.0MUnderstanding how metabolic heterogeneity in cancer affects the tumor microenvironment and anti-tumor immunityR01CA240909 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI KAECH, SUSAN M · 2020 to 2024
$3.0MQuantitative and Spatially-Resolved Analysis of the Tumor Immune Contexture for Optimal Diagnosis and Treatment of Lung CancerR37CA245154 · NCI · YALE UNIVERSITY · PI SCHALPER, KURT A · 2020 to 2025
$2.6MUnderstanding the role and clinical potential of dominant immune suppressive myeloid-cell responses in human cancerR01CA262377 · NCI · YALE UNIVERSITY · PI SCHALPER, KURT A · 2021 to 2025
$1.9MMultiplex imaging in therapy refractory tumors: understanding the spatiotemporal facets of an immunosuppressive environmentR00GM147841 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Vivien Ileana Maltez · 2024 to 2026
$746kBD FACSAria Fusion for Flow Cytometry Core FacilityS10OD023689 · OD · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHENG, YE · 2018 to 2018
$530kMetabolic rewiring regulates cancer growth and tumor-associated immune responsesK00CA222741 · NCI · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI ZHAO, STEVEN · 2020 to 2023
$348kNCATS NIH HHS UL1 TR001863NCI NIH HHS K00 CA222741NCI NIH HHS P30 CA014195NCI NIH HHS P30 CA023100NCI NIH HHS P50 CA196530NCI NIH HHS R01 CA216101NCI NIH HHS R01 CA240909NCI NIH HHS R01 CA262377NCI NIH HHS R37 CA245154NIGMS NIH HHS K99 GM147841NIGMS NIH HHS R00 GM147841NIH HHS S10 OD023689
Abstract
CD8
Indexed as
CatecholaminesCD8-Positive T-LymphocytesReceptors, Adrenergic, beta-1Sympathetic Nervous SystemT-Cell ExhaustionAntigensCell ProliferationHumansImmune Checkpoint InhibitorsMelanomaMemory T CellsPancreatic NeoplasmsStress, PhysiologicalADRB1 protein, humanAntigensCatecholaminesImmune Checkpoint InhibitorsReceptors, Adrenergic, beta-1
Identifiers
What OpenQuestion holds
Textmetadata
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Read underepoch 390
Registered trials
NCT07187284ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.