ArticleNature2023
Acetyl-methyllysine marks chromatin at active transcription start sites.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Beyond acetylation: Evaluating the emerging biology of lysine acylation.Cell chemical biology · 2026Review
- Linking cellular metabolism to chromatin modifications in plants.Journal of integrative plant biology · 2026Review
- Histone H4 acetyl-methyllysine marks accessible chromatin that resists compaction.bioRxiv : the preprint server for biology · 2026Article
- Site-Specific incorporation of lysine acetyl-methylation into proteins.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Article
- Histone deacetylases: Function in tumor development and therapeutic prospects (Review).Oncology letters · 2026Review
- Biochemistry and regulation of histone lysine L-lactylation.Nature reviews. Molecular cell biology · 2026Review
- Untargeted metabolomics reveals immune-metabolic signatures in established cases of rheumatoid arthritis.Frontiers in molecular biosciences · 2026Article
- Maternal histone methyltransferases antagonistically regulate autosomal random monoallelic expression (aRMAE) in C. elegans.Nature communications · 2025Article
- MYOD represses gene expression from non-E-box motifs.Genes & development · 2025Article
- Mechanisms of metabolism-coupled protein modifications.Nature chemical biology · 2025Review
- Post-translational modifications of epigenetic modifier TIP60: their role in cellular functions and cancer.Epigenetics & chromatin · 2025Review
- Optimized Directed Evolution of E. coli leucyl-tRNA Synthetase adds many Noncanonical Amino Acids into the Eukaryotic Genetic Code Including Ornithine and NAngewandte Chemie (International ed. in English) · 2025Article
- Ubiquitin is directly linked via an ester to protein-conjugated mono-ADP-ribose.The EMBO journal · 2025Article
- Role and mechanisms of histone methylation in osteogenic/odontogenic differentiation of dental mesenchymal stem cells.International journal of oral science · 2025Review
- Genetically encoding ε-N-methacryllysine into proteins in live cells.Nature communications · 2025Article
- Development of a High-Throughput Platform for Quantitation of Histone Modifications on a New QTOF Instrument.Molecular & cellular proteomics : MCP · 2025Article
- CRISPR-Activation: Boosting Expression of Plant MIRs.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Circular Engineered Sortase for Interrogating Histone H3 in Chromatin.Journal of the American Chemical Society · 2024Article
- E-box independent chromatin recruitment turns MYOD into a transcriptional repressor.bioRxiv : the preprint server for biology · 2024Article
- Epigenetic therapies targeting histone lysine methylation: complex mechanisms and clinical challenges.The Journal of clinical investigation · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 2 institutions in 1 country.
William J Lu-Culligan *Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA.ORCID 0000-0002-4703-2451
Leah J Connor *Department of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA.
Yixuan XieDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.ORCID 0000-0002-8512-6053
Babatunde E EkundayoDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA.
Brendan T RoseDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA.
Martin MachynaDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA.ORCID 0000-0002-3624-3472
Andreas P Pintado-UrbancDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA.
Joshua T ZimmerDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA.
Isaac W VockDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA.
Natarajan V BhanuDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.
Megan C KingDepartment of Cell Biology, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-1688-2226
Benjamin A GarciaDepartment of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO, USA.
Franziska BleichertDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA.ORCID 0000-0003-0014-770X
Matthew D SimonDepartment of Molecular Biophysics & Biochemistry, Yale University, New Haven, CT, USA. matthew.simon@yale.edu.ORCID 0000-0001-7423-5265
Yale University · USWashington University in St. Louis · US
Funding
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007205 · NIGMS · YALE UNIVERSITY · PI KAZMIERCZAK, BARBARA I · 1985 to 2019
$42.9MSkill Development for Diverse Scientific Careers: A New Course Predoctoral Program in Cellular and Molecular BiologyT32GM007223 · NIGMS · YALE UNIVERSITY · PI BASERGA, SUSAN J · 1985 to 2019
$31.0MSTRUCTURAL BASIS FOR EPIGENETICS IN AGING AND LONGEVITYP01AG031862 · NIA · WISTAR INSTITUTE · PI GARCIA, BENJAMIN A · 2008 to 2022
$28.3MShared Resources Core 2: Quantitative Proteomics CoreP01CA196539 · NCI · ROCKEFELLER UNIVERSITY · PI MUIR, TOM · 2015 to 2024
$17.6MPredoc Training at the Interface Chemistry and BiologyT32GM067543 · NIGMS · YALE UNIVERSITY · PI CRAWFORD, JASON MICHAEL · 2003 to 2022
$7.4MViral modulation of epitranscriptomic mechanismsR01AI118891 · NIAID · WASHINGTON UNIVERSITY · PI GARCIA, BENJAMIN A, WEITZMAN, MATTHEW D. · 2015 to 2025
$5.4MQuantitative mass spectrometry for comprehending epigenetic mechanisms in a new underlying neurological developmental disorderR01HD106051 · NICHD · WASHINGTON UNIVERSITY · PI Benjamin A Garcia · 2022 to 2026
$2.6MRevealing the dynamics of RNA metabolism with nucleotide recoding chemistryR01GM137117 · NIGMS · YALE UNIVERSITY · PI Matthew David Simon · 2020 to 2026
$2.6MIntegrating RNAs into signaling pathways by engineering covalent RNA modificationDP2HD083992 · NICHD · YALE UNIVERSITY · PI SIMON, MATTHEW DAVID · 2014 to 2014
$2.5MMechanisms for recruitment and function of metazoan replication initiation factorsR01GM141313 · NIGMS · YALE UNIVERSITY · PI BLEICHERT, FRANZISKA · 2021 to 2025
$1.7MNCI NIH HHS P01 CA196539NIAID NIH HHS R01 AI118891NIA NIH HHS P01 AG031862NICHD NIH HHS DP2 HD083992NICHD NIH HHS R01 HD106051NIGMS NIH HHS R01 GM137117NIGMS NIH HHS R01 GM141313NIGMS NIH HHS T32 GM007205NIGMS NIH HHS T32 GM007223NIGMS NIH HHS T32 GM067543
Abstract
Lysine residues in histones and other proteins can be modified by post-translational modifications that encode regulatory information
Indexed as
AcetylationChromatinLysineMethylationProtein Processing, Post-TranslationalTranscription Initiation SiteAnimalsBromodomain Containing ProteinsHistone DeacetylasesHistonesHumansPeptidesTranscription FactorsBRD2 protein, humanBromodomain Containing ProteinsChromatinHistone DeacetylasesHistonesLysinePeptidesTranscription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.