Evidence map›Paper›PMID 37730991›Full record

ArticleNature2023

Cryo-EM structures reveal native GABA

Chang Sun, Hongtao Zhu, Sarah Clark, Eric Gouaux

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 72 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Molecular assemblies and pharmacology of cerebellar GABAProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM.Protein science : a publication of the Protein Society · 2026
    Article
  9. GABAFrontiers in immunology · 2026
    Article
  10. Structural Mechanism of Prestin-Membrane Mechanotransduction.bioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Asymmetric gating of a homopentameric ion channel GLIC revealed by cryo-EM.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  18. Article
  19. Solvation Energetic Costs of Cognate Binding Site Formation.Journal of chemical information and modeling · 2025
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Chang SunVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Hongtao ZhuVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Sarah ClarkVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Eric GouauxVollum Institute, Oregon Health and Science University, Portland, OR, USA. gouauxe@ohsu.edu.ORCID 0000-0002-8549-2360
Oregon Health & Science University · USHoward Hughes Medical Institute · USOregon State University · US

Funding

Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Grace B Gill · 1997 to 2026
$60.5M
Pacific Northwest Center for Cryo-EM - Screening supplementU24GM129547 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI EVANS, JAMES E, GOUAUX, JAMES E · 2018 to 2023
$54.8M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Kate E Keller · 1995 to 2026
$19.4M
Structural biology of neurotransmitter ion channelsR01GM100400 · NIGMS · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOUAUX, JAMES E · 2012 to 2020
$2.3M
LTQ Orbitrap VelosS10OD012246 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAVID, LARRY L · 2012 to 2012
$854k
LTQ XL Linear Ion Trap Mass SpectrometerS10RR025571 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI DAVID, LARRY L · 2009 to 2009
$389k
NCI NIH HHS P30 CA069533NCRR NIH HHS S10 RR025571NEI NIH HHS P30 EY010572NIGMS NIH HHS R01 GM100400NIGMS NIH HHS U24 GM129547NIH HHS S10 OD012246
6 · The paper itself

Abstract

Type A γ-aminobutyric acid receptors (GABA

Indexed as

Cryoelectron Microscopygamma-Aminobutyric AcidNeurosteroidsReceptors, GABA-AAnimalsBinding SitesDepression, PostpartumFlurazepamHypnotics and SedativesIon Channel GatingMicePhotobleachingPregnanoloneProtein ConformationProtein SubunitsSleep Initiation and Maintenance DisordersFlurazepamgamma-Aminobutyric AcidHypnotics and SedativesNeurosteroidsPregnanoloneProtein SubunitsReceptors, GABA-AZolpidem

Identifiers

PMID37730991
PMCPMC10550821
OpenAlexW4386886575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.