Trial reportNature2023
Cingulate dynamics track depression recovery with deep brain stimulation.
Registry-linked trialAbstract readClinical Trial
In one paragraph
Trial report in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06784388 (Clinical Application of Personalized DBS Target Optimization for Treating Depression), which is not on this map. Cited by 138 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
NCT06784388 early_phase1recruitingnot on this mapstarted 2025, after this paper: background citation
Clinical Application of Personalized DBS Target Optimization for Treating Depression
Who cites it
138 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Subcallosal cingulate functional connectivity in depression: a systematic review of brain stimulation-induced changes and pretreatment connectivity predictors.Translational psychiatry · 2026Pooled it
- Applications of machine learning in deep brain stimulation for major depressive disorder: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Adaptive deep brain stimulation for dynamic gait control in Parkinson's disease: a randomized feasibility trial.Nature medicine · 2026Trial
- Human intracranial signal stability tracks anatomical accuracy after electrode reimplantation.Journal of neural engineering · 2026Trial
- Bed nucleus of the stria terminalis-nucleus accumbens stimulation for depression: A randomized, double-blind, crossover trial.Cell reports. Medicine · 2026Trial
- Prefrontal-bed nucleus of the stria terminalis physiological and neuropsychological biomarkers predict therapeutic outcomes in depression.Nature communications · 2025Trial
- Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial.Nature medicine · 2024Trial
- Neuromodulation for restoring and amplifying brain function.Nature neuroscience · 2026Review
- Hippocampal-cingulate dynamics in the human brain link reinforcement-learning and memory.bioRxiv : the preprint server for biology · 2026Article
- The mPFC-reuniens-hippocampus pathway links brain circuitry and neural plasticity in antidepressant response.Nature communications · 2026Article
- Adaptive brain stimulation 2.0 for Parkinsonian gait.Nature medicine · 2026Article
- Next-Generation Neuromodulation for Anxiety: Circuit-Based and Personalized Approaches.Current psychiatry reports · 2026Review
- From Iron to Depression: The Crosstalk Between the Periphery and Brain.Neuroscience bulletin · 2026Review
- Diagnostic and sex effects on frontostriatal brain wiring structural organization in early psychosis affective subjects compared to healthy controls.Molecular psychiatry · 2026Article
- Circuit response to neuromodulation characterized with simultaneous deep brain stimulation and precision neuroimaging in humans.Nature neuroscience · 2026Article
- DBS: from neuromodulation to neuroremodelling.Nature neuroscience · 2026Article
- NAcLat-DBS reduces GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks.Nature neuroscience · 2026Article
- Computational Insights Into Smart Bioelectronics in Digital Health Care (2020-2024): Topic Modeling Study.JMIR medical informatics · 2026Review
- Electrical signatures of divergent connectivity in the human subgenual cingulate cortex.medRxiv : the preprint server for health sciences · 2026Article
78 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Sankaraleengam AlagapanSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-2056-5450
Ki Sueng Choi *Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Stephen Heisig *Nash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Patricio Riva-PosseDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Andrea CrowellDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Vineet TiruvadiWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Mosadoluwa ObatusinNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ashan VeerakumarDepartment of Psychiatry, Schulich School of Medicine and Dentistry at Western University, London, Ontario, Canada.
Allison C WatersNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert E GrossWallace H. Coulter Department of Biomedical Engineering at Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Sinead QuinnDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Lydia DenisonEmory University School of Medicine, Atlanta, GA, USA.
Matthew O'ShaughnessySchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Marissa ConnorSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.
Gregory CanalSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-5136-2189
Jungho ChaNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-1189-2051
Rachel HershenbergDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Tanya NauvelNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Faical IsbaineDepartment of Neurosurgery, Emory University School of Medicine, Atlanta, GA, USA.
Muhammad Furqan AfzalNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-8476-4539
Martijn FigeeNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-3679-284X
Brian H KopellNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert ButeraSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0002-1806-0621
Helen S MaybergNash Family Center for Advanced Circuit Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. helen.mayberg@mssm.edu.ORCID 0000-0002-1672-2716
Christopher J RozellSchool of Electrical and Computer Engineering, Georgia Institute of Technology, Atlanta, GA, USA. crozell@gatech.edu.ORCID 0000-0001-5173-1661
Funding
Implementing a Maternal health and PRegnancy Outcomes Vision for Everyone (IMPROVE)UL1TR002378 · NCATS · EMORY UNIVERSITY · PI Andres J Garcia, Elizabeth O. Ofili · 2017 to 2026
$92.1MInstitutional Career Development CoreKL2TR002381 · NCATS · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Anandi Nayan Sheth · 2017 to 2026
$14.1MNeuro HPA Project 1U54AG062334 · NIA · EMORY UNIVERSITY · PI Ighovwerha Ofotokun · 2018 to 2026
$12.2MElectrophysiological Biomarkers to Optimize DBS for DepressionUH3NS103550 · NINDS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MAYBERG, HELEN S, RIVA-POSSE, PATRICIO · 2017 to 2023
$7.7MData Archive for the Brain Initiative (DABI)R24MH114796 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUNCAN, DOMINIQUE, POURATIAN, NADER · 2018 to 2023
$6.2MEmory University BIRCWH ProgramK12AR084234 · NIAMS · EMORY UNIVERSITY · PI Vasiliki Michopoulos, CLAIRE E STERK · 2024 to 2026
$2.6MNCATS NIH HHS KL2 TR002381NCATS NIH HHS UL1 TR002378NIAMS NIH HHS K12 AR084234NIA NIH HHS U54 AG062334NIMH NIH HHS R24 MH114796NINDS NIH HHS UH3 NS103550
Abstract
Deep brain stimulation (DBS) of the subcallosal cingulate (SCC) can provide long-term symptom relief for treatment-resistant depression (TRD)
Indexed as
Deep Brain StimulationDepressionMajor Depressive DisorderArtificial IntelligenceBiomarkersElectrophysiologyFacial ExpressionHumansLimbic LobeLocal Field Potential MeasurementTreatment OutcomeWhite MatterBiomarkers
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT06784388ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.