ArticleNature2023
A multi-stem cell basis for craniosynostosis and calvarial mineralization.
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Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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58citing papers in PubMed
20.4field-weighted citation impact, top 1% of its field
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58 citing papers in PubMed, 65 citations in OpenAlex.
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- Extracellular matrix-inspired multi-morphology microspheres harness osteogenic-prone stem cells to recruit and reprogram adjacent stem cells for synergistic bone regeneration.Journal of advanced research · 2026Article
- Decoding growth hormone actions on human growth plate stem cells.Trends in endocrinology and metabolism: TEM · 2026Article
- Fzd7 Restrains Pink1-Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Roles of integrin β1 and discoidin domain receptor 2 in cranial regeneration and skeletal progenitor cell function.International journal of oral science · 2026Article
- Regional diversity of cranial skeletal stem cells governs bone morphogenetic protein-2 mediated bone regeneration.Nature communications · 2026Article
- Fgfr3-Wnt signaling crosstalk is involved in maintaining cranial suture integrity.Bone research · 2026Article
- ERK-Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- A 3D Tissue-Engineering Model of Craniosynostosis to Study the Microenvironmental Signals Leading to Premature Suture Ossification.Bioengineering (Basel, Switzerland) · 2026Article
- Identification of a Tenochondral Ossification Sequence Producing Heterotopic Ossification in Human Achilles Tendinopathy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026Article
- A novel non-invasive approach monitoring skeletal stem cell function throughJournal of orthopaedic translation · 2026Article
- Trends and insights in non-syndromic craniosynostosis research globally: a bibliometric analysis of the Web of Science database (2005-2024).Translational pediatrics · 2026Article
- The role of Pth1r in posterior cranium cartilage regulation and craniosynostosis.Nature communications · 2026Article
- Divergent Mechanisms of Cranial Suture Ossification in Normal Development and Pathologic Fusion.Journal of cellular and molecular medicine · 2026Review
- Discoidin Domain Receptor 2 Is Required for Tooth Extraction Socket Healing.Journal of dental research · 2026Article
- Bridging skeletal stem cell diversity and human skeletal modeling.Journal of bone and mineral metabolism · 2026Review
- MSC Membrane-Coated circPROSC-siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Human cranial stem cells: developmental, pathologic, and therapeutic implications.Frontiers in cell and developmental biology · 2026Review
- P38α MAPK-induced senescence in cranial suture progenitor cells promotes craniosynostosis.Communications biology · 2025Article
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Authors and funding
25 authors at 5 institutions in 1 country.
Seoyeon BokDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-6063-1224
Alisha R YallowitzDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
Jun SunDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-9099-1829
Jason McCormickFlow Cytometry Core Facility, Weill Cornell Medicine, New York, NY, USA.ORCID 0009-0007-0052-4727
Michelle CungDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2457-4266
Lingling HuDepartment of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.ORCID 0000-0002-1797-7390
Sarfaraz LalaniDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-3624-9409
Zan LiDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-4873-4471
Branden R SosaDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-1054-2917
Tomas BaumgartnerFlow Cytometry Core Facility, Weill Cornell Medicine, New York, NY, USA.
Paul ByrneFlow Cytometry Core Facility, Weill Cornell Medicine, New York, NY, USA.
Tuo ZhangGenomics Resources Core Facility, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-5396-918X
Kyle W MorseDepartment of Orthopedic Surgery, Hospital for Special Surgery, New York, NY, USA.
Fatma F MohamedDepartment of Periodontics, Prevention and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
Chunxi GeDepartment of Periodontics, Prevention and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-7719-1077
Renny T FranceschiDepartment of Periodontics, Prevention and Geriatrics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-1405-2541
Randy T CowlingDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, CA, USA.ORCID 0000-0001-5815-1512
Barry H GreenbergDivision of Cardiovascular Medicine, Department of Medicine, University of California, San Diego, CA, USA.
David J PisapiaDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-1528-8425
Thomas A ImahiyeroboDivision of Plastic Surgery, Department of Surgery, New York-Presbyterian Hospital and Columbia University Medical Center, New York, NY, USA.
Shenela LakhaniCenter for Neurogenetics, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
M Elizabeth RossCenter for Neurogenetics, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-6440-8089
Caitlin E HoffmanDepartment of Neurological Surgery, Weill Cornell Medicine and New York-Presbyterian Hospital, New York, NY, USA.
Shawon DebnathDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. shd2030@med.cornell.edu.ORCID 0000-0003-2164-1213
Matthew B GreenblattDepartment of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. mag3003@med.cornell.edu.ORCID 0000-0001-9794-8532
Cornell University · USHospital for Special Surgery · USUniversity of Michigan · USNewYork–Presbyterian Hospital · USUniversity of California San Diego · US
Funding
Weill Cornell Medicine (WCM) SPORE in Prostate CancerP50CA211024 · NCI · WEILL MEDICAL COLL OF CORNELL UNIV · PI GUDAS, LORRAINE J · 2017 to 2021
$10.9MStructure, Composition, & Histology Core - Core BP30AR069620 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARL J JEPSEN · 2016 to 2026
$8.4MDiscoidin Domain Receptor 2, β1 Integrins and ECM Control of Bone FormationR01DE029465 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2021 to 2025
$2.4MHSS Research Institute Rheumatology TrainingT32AR071302 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI ALESSANDRA B PERNIS, Jane E Salmon · 2017 to 2026
$2.3MModulation of Bone Formation by SHN3DP5OD021351 · OD · WEILL MEDICAL COLL OF CORNELL UNIV · PI GREENBLATT, MATTHEW BLAKE · 2015 to 2019
$2.1M"Establishing Pathways for Endothelial Support of Bone Formation with SLIT3"R01AR075585 · NIAMS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GREENBLATT, MATTHEW BLAKE · 2020 to 2024
$1.8MCombined Engineering and Orthopaedics Training ProgramT32AR078751 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI MAHER, SUZANNE A., VAN DER MEULEN, MARJOLEIN C · 2021 to 2025
$1.7MDiscoidin domain receptor 2, a novel regulator of bone regenerationR21DE029012 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FRANCESCHI, RENNY THEODORE · 2019 to 2020
$429kA multi-stem cell basis for CraniosynostosisK99DE031819 · NIDCR · WEILL MEDICAL COLL OF CORNELL UNIV · PI DEBNATH, SHAWON · 2022 to 2023
$270kNCI NIH HHS P50 CA211024NIAMS NIH HHS P30 AR069620NIAMS NIH HHS R01 AR075585NIAMS NIH HHS T32 AR071302NIAMS NIH HHS T32 AR078751NIDCR NIH HHS K99 DE031819NIDCR NIH HHS R01 DE029465NIDCR NIH HHS R21 DE029012NIH HHS DP5 OD021351
Abstract
Craniosynostosis is a group of disorders of premature calvarial suture fusion. The identity of the calvarial stem cells (CSCs) that produce fusion-driving osteoblasts in craniosynostosis remains poorly understood. Here we show that both physiologic calvarial mineralization and pathologic calvarial fusion in craniosynostosis reflect the interaction of two separate stem cell lineages; a previously identified cathepsin K (CTSK) lineage CSC
Indexed as
CraniosynostosesAnimalsCell LineageHumansMiceOsteogenesisPhenotypeStem Cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.