ArticleArchives of women's mental health2024
Sex differences in schizophrenia-spectrum diagnoses: results from a 30-year health record registry.
Article in Archives of women's mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Clinical outcomes in first-episode psychoses: does age at admission matter?European archives of psychiatry and clinical neuroscience · 2026Article
- Risk of Schizophrenia Spectrum Disorders Following Parkinson's Disease: A Nationwide Population-Based Cohort Study.Psychiatry investigation · 2026Article
- Sex-specific drivers of non-affective psychotic disorders within migrant groups: A 25-year retrospective cohort study of 2 million migrants.Social psychiatry and psychiatric epidemiology · 2026Article
- The Brain Endocannabinoid System is Differentially Regulated in Male and Female Patients with First-Episode Psychosis.Schizophrenia bulletin · 2026Article
- Women's Care in First-Episode Psychosis: Clinicians' Perspectives on Service Provision.Early intervention in psychiatry · 2026Article
- Psychiatric Hospitalization After Enrollment in Coordinated Specialty Care: Unexpected Gender- and Age-Related Disparities.Schizophrenia bulletin · 2026Article
- Sex Differences in Schizophrenia Across the Reproductive Lifespan.Current psychiatry reports · 2026Review
- Genetics to Improve Outcomes in Schizophrenia (GENios): A within-case molecular genetic study protocol.PloS one · 2026Article
- Ensuring generalizability and clinical utility in mental health care applications: Robust artificial intelligence-based treatment predictions in diverse psychosis populations.Psychiatry and clinical neurosciences · 2026Article
- Psychiatric Hospitalization After Enrollment in Coordinated Specialty Care: Unexpected Gender and Age Related Disparities.medRxiv : the preprint server for health sciences · 2025Article
- Machine learning for novel phenotyping in schizophrenia.Schizophrenia research · 2025Article
- Sex differences in schizophrenia spectrum disorders: insights from the DiAPAson study using a data-driven approach.Social psychiatry and psychiatric epidemiology · 2025Article
- Narcolepsy: Beyond the Classic Pentad.CNS drugs · 2025Review
- Demographic, Premorbid, and Clinical Characteristics of Schizophrenia Spectrum Patients with High and Low Polygenic Liability to the Disorder.Diseases (Basel, Switzerland) · 2025Article
- Sex differences in outcomes of first episode psychosis: results from an early intervention service.Frontiers in behavioral neuroscience · 2025Article
- Global Burden of Schizophrenia Among Women of Reproductive Age from 1990 to 2021: Trends, Inequalities, and Projections to 2040.Women's health reports (New Rochelle, N.Y.) · 2025Article
- Clinical effects of CYP2D6 phenoconversion in patients with psychosis.Journal of psychopharmacology (Oxford, England) · 2024Article
- Gonadal hormone abnormalities in young patients with first-episode schizophrenia.The international journal of neuropsychopharmacology · 2024Article
- Prenatal Exposure to MAM Impairs mPFC and Hippocampal Inhibitory Function in Mice during Adolescence and Adulthood.eNeuro · 2024Article
- An Evaluation of a Women's Clinic: The Healthcare and Learning Project of the Functional Unit for Women with Schizophrenia.Healthcare (Basel, Switzerland) · 2024Review
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 5 countries.
Funding
Abstract
This study investigated sociodemographic and clinical differences between the sexes in individuals affected by schizophrenia-spectrum disorders (SSD) who accessed outpatient mental health services. Within a retrospective cohort of 45,361 outpatients receiving care in Ferrara (Italy) from 1991 to 2021, those with a SSD diagnosis were compared between the sexes for sociodemographic and clinical characteristics before and after the index date (when the ICD-9: 295.*diagnosis was first recorded) to assess early trajectory, age and type of diagnosis, and severity of illness indicated by medication use, hospitalization, and duration of psychiatric care. Predictors of discharge were also investigated. Among 2439 patients, 1191 were women (48.8%). Compared to men, women were significantly older at first visit (43.7 vs. 36.8 years) and at index date (47.8 vs. 40.6) with peak frequency at age 48 (vs. 30). The most frequent last diagnosis recorded before the index date was delusional disorder (27.7%) or personality disorder (24.3%) in men and depression (24%) and delusional disorder (30.1%) in women. After the index date, long-acting antipsychotics and clozapine were more frequently prescribed to men (46.5% vs. 36.3%; 13.2% vs. 9.4%, p < 0.05) and mood stabilizers and antidepressants to women (24.3% vs. 21.1%; 50.1% vs. 35.5%; p < 0.05). Women had fewer involuntary admissions (10.1% vs. 13.6%) and were more likely to be discharged as the time under care increased (p = 0.009). After adjusting for covariates, sex was not a significant predictor of discharge. Our study confirmed that sex differences exist in clinical and sociodemographic characteristics of outpatients with SSD and that gender considerations might influence the rapidity of diagnosis and medications prescribed. These findings highlight the need to implement a women-tailored approach in specialist care programs for psychoses.
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Registered trials
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