ArticleMolecular psychiatry2023
The PFC-LH-VTA pathway contributes to social deficits in IRSp53-mutant mice.
Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Sex Differences on Social and Anxiety-Related Responses in Low-Density Lipoprotein Receptor Knockout Mice.Molecular neurobiology · 2026Article
- Differential brain activation and network connectivity in social interactions presence and absence of physical contact.Communications biology · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Restoring social deficits in IRSp53-deleted mice: chemogenetic inhibition of ventral dentate gyrus Emx1-expressing cells.Translational psychiatry · 2024Article
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Dopamine (DA) neurons in the ventral tegmental area (VTA) promote social brain functions by releasing DA onto nucleus accumbens neurons, but it remains unclear how VTA neurons communicate with cortical neurons. Here, we report that the medial prefrontal cortex (mPFC)-lateral hypothalamus (LH)-VTA pathway contributes to social deficits in mice with IRSp53 deletion restricted to cortical excitatory neurons (Emx1-Cre;Irsp53
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