Trial reportScientific reports2023
Assessment of safety and intranasal neutralizing antibodies of HPMC-based human anti-SARS-CoV-2 IgG1 nasal spray in healthy volunteers.
Open access · goldAbstract readRandomized Controlled Trial
In one paragraph
Trial report in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Saline nasal irrigation and gargling in COVID-19: Part II. Outcomes in Omicron and risk-benefit for self-care.Frontiers in public health · 2025Pooled it
- Colostrum from MERS-CoV seropositive camels for MERS prophylaxis and SARS-CoV-2 infection, a placebo controlled randomized trial.Scientific reports · 2025Trial
- Human monoclonal antibody F61 nasal spray effectively protected high-risk populations from SARS-CoV-2 variants during the COVID-19 pandemic from late 2022 to early 2023 in China.Emerging microbes & infections · 2024Trial
- A comprehensive strategy for pandemic preparedness with neutralizing monoclonal antibodies.mAbs · 2025Article
- Drum Filling of Thin-Film Freeze-Dried Monoclonal Antibody Powder in UniDose Powder Nasal Spray System.Pharmaceutical research · 2025Article
- Spray-Dried Serum for Inhaled Antiviral Therapy.Pharmaceutics · 2025Article
- Intranasal monoclonal antibodies do not prevent respiratory infection in a randomized, controlled experimental infection trial.npj drug discovery · 2025Article
- Real world effectiveness of early ensitrelvir treatment in patients with SARS-CoV-2, a retrospective case series.New microbes and new infections · 2024Article
- Article
- Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trial.EClinicalMedicine · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
46 authors at 9 institutions in 3 countries.
Thanarath ImsuwansriDepartment of Medical Services, National Cancer Institute, Ministry of Public Health, Bangkok, Thailand. drthanarath@gmail.com.
Thitinan JongthitinonDepartment of Medical Services, National Cancer Institute, Ministry of Public Health, Bangkok, Thailand.
Niramon PojdoungDepartment of Medical Services, National Cancer Institute, Ministry of Public Health, Bangkok, Thailand.
Nuntana MeesiripanDepartment of Medical Services, National Cancer Institute, Ministry of Public Health, Bangkok, Thailand.
Siriwan SakarinDepartment of Medical Services, National Cancer Institute, Ministry of Public Health, Bangkok, Thailand.
Chatikorn BoonkraiFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, Thailand.
Tossapon WongtangprasertFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, Thailand.
Tanapati PhakhamFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, Thailand.
Thittaya AudomsunFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, Thailand.
Chadaporn AttakitbanchaFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, Thailand.
Pijitra SaelaoFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, Thailand.
Phijitra MuanwienFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, Thailand.
Maoxin Tim TianFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, Thailand.
Songsak TongchusakFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, Thailand.
Bhrus SangrujiSchool of Arts and Sciences, Tufts University, Massachusetts, USA.
Dhammika Leshan WannigamaDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chenphop SawangmakeDepartment of Pharmacology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Watchareewan RodprasertFaculty of Veterinary Science, Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC), Chulalongkorn University, Bangkok, Thailand.
Quynh Dang LeFaculty of Veterinary Science, Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC), Chulalongkorn University, Bangkok, Thailand.
Steven Dwi PurbantoroFaculty of Veterinary Science, Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC), Chulalongkorn University, Bangkok, Thailand.
Kananuch VasuntrarakDepartment of Pharmacology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand.
Sirirat NantavisaiFaculty of Veterinary Science, Veterinary Stem Cell and Bioengineering Innovation Center (VSCBIC), Chulalongkorn University, Bangkok, Thailand.
Supakit SirilakDepartment of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Ballang UppapongDepartment of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
Sompong SapsutthipasDepartment of Medical Sciences, Institute of Biological Products, Ministry of Public Health, Nonthaburi, Thailand.
Sakalin TrisiriwanichDepartment of Medical Sciences, Institute of Biological Products, Ministry of Public Health, Nonthaburi, Thailand.
Thitiporn SompornDepartment of Medical Sciences, Institute of Biological Products, Ministry of Public Health, Nonthaburi, Thailand.
Asmah UsooDepartment of Medical Sciences, Institute of Biological Products, Ministry of Public Health, Nonthaburi, Thailand.
Natthakarn MingngamsupDepartment of Medical Sciences, Institute of Biological Products, Ministry of Public Health, Nonthaburi, Thailand.
Supaporn PhumiamornDepartment of Medical Sciences, Institute of Biological Products, Ministry of Public Health, Nonthaburi, Thailand.
Porawan AumkladFaculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand.
Kwanputtha ArunprasertFaculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand.
Prasopchai PatrojanasophonFaculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand.
Praneet OpanasopitFaculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand.
Norapath PesirikanThe Government Pharmaceutical Organization, Bangkok, Thailand.
Ladda NitisapornThe Government Pharmaceutical Organization, Bangkok, Thailand.
Jesada PitchayakornThe Government Pharmaceutical Organization, Bangkok, Thailand.
Thana NarkthongThe Government Pharmaceutical Organization, Bangkok, Thailand.
Bancha MahongThe Government Pharmaceutical Organization, Bangkok, Thailand.
Kumchol ChaiyoThe Government Pharmaceutical Organization, Bangkok, Thailand.
Kanjana SrisutthisamphanVirology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani, Thailand.
Ratchanont ViriyakitkosolVirology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani, Thailand.
Songklot AeumjaturapatOtolaryngology Department, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Anan JongkaewwattanaVirology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathumthani, Thailand.
Sakarn BunnagDepartment of Medical Services, National Cancer Institute, Ministry of Public Health, Bangkok, Thailand.
Trairak PisitkunFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, Thailand. trairak@gmail.com.
Chulalongkorn University · THMinistry of Public Health · THGovernment of Thailand · THDepartment of Medical Sciences · THSilpakorn University · THKing Chulalongkorn Memorial Hospital · THNational Center for Genetic Engineering and Biotechnology · THNational Science and Technology Development Agency · THTufts University · US
Funding
No grant is acknowledged in the PubMed record.
Abstract
An HPMC-based nasal spray solution containing human IgG1 antibodies against SARS-CoV-2 (nasal antibody spray or NAS) was developed to strengthen COVID-19 management. NAS exhibited potent broadly neutralizing activities against SARS-CoV-2 with PVNT
Indexed as
COVID-19Nasal SpraysAdministration, IntranasalAnimalsAntibodies, NeutralizingAntibodies, ViralHealthy VolunteersHumansImmunoglobulin GRatsSARS-CoV-2Antibodies, NeutralizingAntibodies, ViralImmunoglobulin GNasal Sprays
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.