Evidence map›Paper›PMID 37730751›Full record

ArticleNature communications2023

Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein.

Kyoko Okada, Bharat R Iyer, Lindsay G Lammers, Pedro A Gutierrez, Wenzhe Li, Steven M Markus, Richard J McKenney

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. The mechanochemical cycle of reactive full-length human dynein 1.Nature structural & molecular biology · 2025
    Article
  8. CCSer2 gates dynein activity at the cell periphery.The Journal of cell biology · 2025
    Article
  9. Nde1 Promotes Lis1 Binding to Full-Length Autoinhibited Human Dynein-1.bioRxiv : the preprint server for biology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. CCSer2 gates dynein activity at the cell periphery.bioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. VezA/vezatin facilitates proper assembly of the dynactin complex in vivo.bioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Review
  18. Article
  19. Nde1 Promotes Lis1-Mediated Activation of Dynein.bioRxiv : the preprint server for biology · 2023
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Kyoko Okada *Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA, 95616, USA.
Bharat R Iyer *Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA.ORCID http://orcid.org/0000-0001-7402-6711
Lindsay G LammersDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA.
Pedro A GutierrezDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, 95616, USA.
Wenzhe LiDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, 95616, USA.ORCID http://orcid.org/0000-0001-8797-8965
Steven M MarkusDepartment of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO, 80523, USA. Steven.Markus@colostate.edu.ORCID http://orcid.org/0000-0002-3098-0236
Richard J McKenneyDepartment of Molecular and Cellular Biology, University of California, Davis, Davis, CA, 95616, USA. rjmckenney@ucdavis.edu.ORCID http://orcid.org/0000-0002-8423-0852
Colorado State University · USUniversity of California, Davis · USColumbia University · US

Funding

Coordination of molecular motor activity in intracellular transport and assembly of cytoskeletal architecture.R35GM124889 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Richard James McKenney · 2017 to 2026
$4.3M
Regulation of Dynein-Mediated Transport.R35GM139483 · NIGMS · COLORADO STATE UNIVERSITY · PI Steven M Markus · 2021 to 2026
$2.9M
Regulation of Cytoplasmic Dynein Motility in Neuronal TransportR00NS089428 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MCKENNEY, RICHARD JAMES · 2016 to 2018
$736k
NIGMS NIH HHS R35 GM124889NIGMS NIH HHS R35 GM139483NINDS NIH HHS R00 NS089428
6 · The paper itself

Abstract

Processive transport by the microtubule motor cytoplasmic dynein requires the regulated assembly of a dynein-dynactin-adapter complex. Interactions between dynein and dynactin were initially ascribed to the dynein intermediate chain N-terminus and the dynactin subunit p150

Indexed as

Cytoplasmic DyneinsDyneinsActin CytoskeletonCytoskeletonDynactin ComplexCytoplasmic DyneinsDynactin ComplexDyneins

Identifiers

PMID37730751
PMCPMC10511499
OpenAlexW4386889890

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.