Evidence map›Paper›PMID 37730733›Full record

ArticleScientific reports2023

Comprehensive analysis of chemokine gene polymorphisms in Korean children with autoimmune thyroid disease.

Chungwoo Shin, In-Cheol Baek, Won Kyoung Cho, Tai-Gyu Kim, Byung-Kyu Suh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chungwoo ShinDepartment of Pediatrics, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul, 065941, Korea.ORCID https://orcid.org/0000-0003-1616-327X
In-Cheol BaekCatholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, 065941, Korea. icbaek@catholic.ac.kr.ORCID https://orcid.org/0000-0003-3630-3364
Won Kyoung ChoDepartment of Pediatrics, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul, 065941, Korea. wendy626@catholic.ac.kr.ORCID https://orcid.org/0000-0003-0918-0565
Tai-Gyu KimCatholic Hematopoietic Stem Cell Bank, College of Medicine, The Catholic University of Korea, Seoul, 065941, Korea.ORCID https://orcid.org/0000-0002-2226-2138
Byung-Kyu SuhDepartment of Pediatrics, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea, Seoul, 065941, Korea.ORCID https://orcid.org/0000-0003-1971-0232
The Catholic University of Korea St. Vincent's Hospital · KRCatholic University of Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemokines are chemotactic cytokines that can cause directed migration of leukocytes. The aim of this study was to examine differences in single nucleotide polymorphisms (SNP) of chemokine in AITD patients compared to normal controls. A total of 86 Korean pediatric patients were included in the patient group and 183 adults were included in the normal control group. To compare influences of several chemokine gene polymorphisms, 25 SNPs in 16 chemokine genes were analyzed. Genotype frequencies of CCL11(rs3744508)AA(OR = 6.9) and CCR2(rs1799864)AA(OR = 3.8) were higher in the AITD patients than in the controls, whereas CCL17(rs223828)CC was lower in the AITD patients than in the controls(OR = 0.4). In comparison between Graves' disease (GD) patients and controls, genotype frequency of CCL17(rs223828)CC(OR = 0.4) was lower in the GD group, whereas those of CCR2(rs1799864)AA(OR = 4.8) were higher in the GD group. The genotype frequency of CCL11(rs3744508)AA(OR = 11.3) was higher in Hashimoto's thyroiditis (HT) patients, whereas that of CXCL8(rs2227306)CC(OR = 0.4) was lower in HT patients. Polymorphisms of CCL11(rs3744508), CCL17(rs223828), and CCR2(rs1799864) might be associated with AITD, with CCL17(rs223828), CCR2(rs1799864) and CXCR2(rs2230054, rs1126579) affecting GD and CCL11(rs3744508) and CXCL8(rs2227306) affecting HT in Korean children.

Indexed as

Graves DiseaseHashimoto DiseaseAdultChildEast Asian PeopleGenotypeHumansPolymorphism, Single NucleotideRepublic of Korea

Identifiers

PMID37730733
PMCPMC10511635
OpenAlexW4386910492

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.