Evidence map›Paper›PMID 37730550›Full record

ArticleBMC cardiovascular disorders2023

MiR-206 may regulate mitochondrial ROS contribute to the progression of Myocardial infarction via TREM1.

Hao Lin, Jiapeng Chu, Deqiang Yuan, Kangwei Wang, Fei Chen, Xuebo Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hao LinDepartment of Cardiology, Tongji Hospital, School of Medicine, Tongji University, No.389, Xincun Road, Shanghai, 200092, Putuo District, China.
Jiapeng ChuDepartment of Cardiology, Tongji Hospital, School of Medicine, Tongji University, No.389, Xincun Road, Shanghai, 200092, Putuo District, China.
Deqiang YuanDepartment of Cardiology, Tongji Hospital, School of Medicine, Tongji University, No.389, Xincun Road, Shanghai, 200092, Putuo District, China.
Kangwei WangDepartment of Cardiology, Tongji Hospital, School of Medicine, Tongji University, No.389, Xincun Road, Shanghai, 200092, Putuo District, China.
Fei ChenDepartment of Cardiology, Tongji Hospital, School of Medicine, Tongji University, No.389, Xincun Road, Shanghai, 200092, Putuo District, China. riverapt@126.com.
Xuebo LiuDepartment of Cardiology, Tongji Hospital, School of Medicine, Tongji University, No.389, Xincun Road, Shanghai, 200092, Putuo District, China. liuxuebo70@hotmail.com.
Tongji Hospital · CNTongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Myocardial infarction (MI) is a leading cause of mortality. To better understand its molecular and cellular mechanisms, we used bioinformatic tools and molecular experiments to explore the pathogenesis and prognostic markers. Differential gene expression analysis was conducted using GSE60993 and GSE66360 datasets. Hub genes were identified through pathway enrichment analysis and PPI network construction, and four hub genes (AQP9, MMP9, FPR1, and TREM1) were evaluated for their predictive performance using AUC and qRT-PCR. miR-206 was identified as a potential regulator of TREM1. Finally, miR-206 was found to induce EC senescence and ER stress through upregulating mitochondrial ROS levels via TREM1. These findings may contribute to understanding the pathogenesis of MI and identifying potential prognostic markers.

Indexed as

MicroRNAsMyocardial InfarctionHumansMitochondriaReactive Oxygen SpeciesTriggering Receptor Expressed on Myeloid Cells-1MicroRNAsMIRN206 microRNA, humanReactive Oxygen SpeciesTREM1 protein, humanTriggering Receptor Expressed on Myeloid Cells-1BioinformaticsHub genesMiRNAMitochondrial ROSMyocardial infarction

Identifiers

PMID37730550
PMCPMC10512505
OpenAlexW4386910346

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.