Evidence map›Paper›PMID 37730436›Full record

ArticleCold Spring Harbor molecular case studies2023

Leukemic presentation and progressive genomic alterations of MCD/C5 diffuse large B-cell lymphoma (DLBCL).

Patricia M Kim, Reza Nejati, Pin Lu, Devang Thakkar, Nicholas Mackrides, Vanessa Dupoux, Shazia Nakhoda, Don A Baldwin, Jianming Pei, Sandeep S Dave and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Cold Spring Harbor molecular case studies, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. BTK inhibitors: past, present, and future.Trends in pharmacological sciences · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Patricia M KimDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Reza NejatiDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Pin LuDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Devang ThakkarDuke University, Durham, North Carolina 27708, USA.
Nicholas MackridesDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Vanessa DupouxDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Shazia NakhodaDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Don A BaldwinDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Jianming PeiDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Sandeep S DaveDuke University, Durham, North Carolina 27708, USA.
Y Lynn WangDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA.
Mariusz A WasikDepartment of Pathology, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111, USA; mariusz.wasik@fccc.edu.
Fox Chase Cancer Center · USDuke University · US

Funding

Metabolic Imaging of Targeted Therapies in CancerR01CA268601 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Kavindra Nath, MARIUSZ A. WASIK · 2022 to 2026
$3.0M
Building clinically faithful ex vivo indolent lymphoma models for personalized therapyR21CA263415 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI WANG, Y. LYNN · 2021 to 2022
$476k
NCI NIH HHS R01 CA268601NCI NIH HHS R21 CA263415
6 · The paper itself

Abstract

Diffuse large B-cell lymphoma (DLBCL) is a heterogenous group of lymphoid malignancies. Based on gene expression profiling, it has been subdivided into germinal center (GC)-derived and activated B-cell (ABC) types. Advances in molecular methodologies have further refined the subclassification of DLBCL, based on recurrent genetic abnormalities. Here, we describe a distinct case of DLBCL that presented in leukemic form. DNA sequencing targeting 275 genes revealed pathogenically relevant mutations of

Indexed as

Aniline CompoundsLymphoma, Large B-Cell, DiffuseNeoplasm Recurrence, LocalPiperidinesGenomicsHumansRituximabAniline CompoundsPiperidinesRituximabvecabrutinibB-cell lymphomahematological neoplasm

Identifiers

PMID37730436
PMCPMC10815299
OpenAlexW4386881480

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.