Evidence map›Paper›PMID 37730197›Full record

ArticleContemporary clinical trials2023

Reaching adults who smoke cigarettes in rural Appalachia: Rationale, design & analysis plan for a mixed-methods study disseminating pharmacy-delivered cessation treatment.

M C Fahey, R A Krukowski, R T Anderson, W F Cohn, K J Porter, T Reid, K P Wiseman, W You, C H Wood, T W Rucker and 1 more

Registry-linked trialOpen access · greenAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05660525 (Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05660525 narecruitingnot on this mapstarted 2024, after this paper: background citation

Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in Appalachia

TypeinterventionalSponsorUniversity of VirginiaRan2024 to 2028Enrolled768ConditionsSmoking Cessation, Smoking, Cigarette, Smoking Reduction, SmokingArms4 weeks of Nicotine lozenge, 8 weeks of Nicotine Replacement Therapy Patch, QuitAid, Smokefree TXT, Tobacco Quitline
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

M C FaheyMedical University of South Carolina, Charleston, SC, USA.
R A KrukowskiUniversity of Virginia, Department of Public Health Sciences, Charlottesville, VA, USA.
R T AndersonUniversity of Virginia, School of Medicine, Charlottesville, VA, USA.
W F CohnUniversity of Virginia, Department of Public Health Sciences, Charlottesville, VA, USA.
K J PorterUniversity of Virginia, Department of Public Health Sciences, Charlottesville, VA, USA.
T ReidUniversity of Virginia, Department of Public Health Sciences, Charlottesville, VA, USA.
K P WisemanUniversity of Virginia, Department of Public Health Sciences, Charlottesville, VA, USA.
W YouUniversity of Virginia, Department of Public Health Sciences, Charlottesville, VA, USA.
C H WoodMy Pharmacy, Greensboro, NC, USA.
T W RuckerUniversity of Virginia, Health Systems, Nellysford, VA, USA.
M A LittleUniversity of Virginia, Department of Public Health Sciences, Charlottesville, VA, USA. Electronic address: mlittle@virginia.edu.
University of Virginia · USGreensboro College · USMedical University of South Carolina · USUniversity of Virginia Health System · US

Funding

Leveraging Community Pharmacists to Optimize Smoking Cessation Services for Rural Smokers in AppalachiaR01CA267963 · NCI · UNIVERSITY OF VIRGINIA · PI Melissa Ashley Little · 2022 to 2026
$4.0M
NCI NIH HHS R01 CA267963
6 · The paper itself

Abstract

introductionUnlike other U.S. geographical regions, cigarette smoking prevalence remains stagnant in rural Appalachia. One avenue for reaching rural residents with evidence-based smoking cessation treatments could be utilizing community pharmacists. This paper describes the design, rationale, and analysis plan for a mixed-method study that will determine combinations of cessation treatment components that can be integrated within community pharmacies in rural Appalachia. The aim is to quantify the individual and synergistic effects of five highly disseminable and sustainable cessation components in a factorial experiment.

methodsThis sequential, mixed-method research design, based on the RE-AIM (Reach, Effectiveness, Adoption, Implementation, and Maintenance) framework, will use a randomized controlled trial with a 2

resultsLogistic regression will model abstinence at six-months, including indicators for the five treatment factors and all two-way interactions between the treatment factors. Demographic and smoking history variables will be considered to assess potential effect modification. Poisson regression will model quit attempts and percent of adherence to treatment components as secondary outcomes.

conclusionThis study will provide foundational evidence on how community pharmacies in medically underserved, rural regions can be leveraged to increase utilization of existing evidence-based tobacco cessation resources for treating tobacco dependence. CLINICAL TRIALS: NCT05660525.

Indexed as

Cigarette SmokingPharmacySmoking CessationAdultHumansNicotineRandomized Controlled Trials as TopicTobacco Use Cessation DevicesNicotineAppalachiafactorial designpharmacyrandomized clinical trialrural healthtobacco cessation

Identifiers

PMID37730197
PMCPMC10841546
OpenAlexW4386827236

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.