ArticleJournal of the American Chemical Society2023
One-Pot Synthesis of Sulfonamides from Unactivated Acids and Amines via Aromatic Decarboxylative Halosulfonylation.
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Enabling Fluoroalkyl-Sulfonylalkylation and Fluoroalkyl-Halogenation of Alkenes and Alkynes via Photoredox Catalysis.Journal of the American Chemical Society · 2026Article
- One-Pot Bioisosteric Replacement of Alkyl Carboxylic Acids via Organic Photoredox Catalysis.Organic letters · 2025Article
- Mixed-Metal Ce-Zr-Mn Clusters as Photo-Catalysts for Decarboxylative Functionalization of Carboxylic Acids.Angewandte Chemie (International ed. in English) · 2025Article
- Accessing sulfonamides via formal SONature chemistry · 2025Article
- Ruthenium Catalyzed Ortho-Arylation Reaction of Benzoic Acids with Arylthianthrenium Salts.Angewandte Chemie (International ed. in English) · 2025Article
- Generation of perthiyl radicals for the synthesis of unsymmetric disulfides.Nature communications · 2025Article
- Bioactive Sulfonamides Derived from Amino Acids: Their Synthesis and Pharmacological Activities.Mini reviews in medicinal chemistry · 2025Review
- Innovative On-Resin and in Solution Peptidomimetics Synthesis via Metal-Free Photocatalytic Approach.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Metal-free introduction of primary sulfonamide into electron-rich aromatics.Chemical science · 2024Article
- Nitro-sulfinate Reductive Coupling to Access (Hetero)aryl Sulfonamides.The Journal of organic chemistry · 2024Article
- Facile Synthesis of 5-Bromo-Infection and drug resistance · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The coupling of carboxylic acids and amines to form amide linkages is the most commonly performed reaction in the pharmaceutical industry. Herein, we report a new strategy that merges these traditional amide coupling partners to generate sulfonamides, important amide bioisosteres. This method leverages copper ligand-to-metal charge transfer (LMCT) to convert aromatic acids to sulfonyl chlorides, followed by one-pot amination to form the corresponding sulfonamide. This process requires no prefunctionalization of the native acid or amine and extends to a diverse set of aryl, heteroaryl, and
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Registered trials
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