ArticlePloS one2023
Minimal clinically-important differences for the "Liverpool Osteoarthritis in Dogs" (LOAD) and the "Canine Orthopedic Index" (COI) in dogs with osteoarthritis.
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Transcranial photobiomodulation therapy with 808 nm and 1064 nm can affect different behavior parameters in dogs.Lasers in medical science · 2026Article
- Effectiveness of a mesotherapy protocol vs. an epidural injection of platelet-rich plasma or methylprednisolone in degenerative lumbosacral stenosis in dogs - a retrospective study.Frontiers in veterinary science · 2026Article
- The Combined Application of Intra-Articular Platelet-Rich Plasma Injections and Photobiomodulation Improves Clinical Outcomes in Dogs with Osteoarthritis-Results of a Long-Term, Double-Blinded, Crossover Study.Veterinary sciences · 2025Article
- Physical Activity Monitors in Companion Animal Chronic Pain Research-A Review Focused on Osteoarthritis Pain.Animals : an open access journal from MDPI · 2025Review
- Small Animal Orthopedic Surgery, Physical Therapy and Rehabilitation.Animals : an open access journal from MDPI · 2025Article
- Advancing outcome measure development and analytical approaches: Pain in Animals Workshop 2023.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Outcome assessment in veterinary pain studies: a pain in animals workshop (PAW) perspective.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- A randomised, parallel-group clinical trial comparing bedinvetmab to meloxicam for the management of canine osteoarthritis.Frontiers in veterinary science · 2025Article
- Efficacy of a joint supplement containing eggshell membrane among other ingredients to improve the mobility of dogs with osteoarthritis: a multicenter double-blind randomized placebo-controlled study.Frontiers in veterinary science · 2025Article
- Response to treatment with grapiprant as part of a standard multimodal regimen in young dogs with appendicular joint osteoarthritis associated pain.Frontiers in veterinary science · 2024Article
- Minimal Clinically Important Differences for a Weight Distribution Platform in Dogs with Osteoarthritis.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveOsteoarthritis is the most common joint disease in companion animals. Several client-report outcome measures (CROMs) have been developed and validated to monitor patients and their response to treatment. However, estimates for minimal clinically-important differences for these CROMs in the context of osteoarthritis have not been published. PATIENTS AND
methodsData from the Clínica Veterinária de Cães (Portuguese Gendarmerie Canine Clinic) clinical records were extracted. Baseline and 30-day post-treatment follow-up data from 296 dogs treated for hip osteoarthritis were categorized based on an anchor question, and estimates of minimal clinically-important differences (MCIDs) using distribution-based and anchor-based methods were performed.
resultsFor the LOAD, the anchor-based methods provided a MCID estimate range of -2.5 to -9.1 and the distribution-based methods from 1.6 to 4.2. For the COI, the anchor-based methods provided a MCID estimate range of -4.5 to -16.6 and the distribution-based methods from 2.3 to 2.4. For the dimensions of COI, values varied from -0.5 to -4.9 with the anchor-based methods and from 0.6 to 2.7 with the distribution-based methods. Receiver operator characteristic curves provided areas under the curve >0.7 for the COI, indicating an acceptable cut-off point, and >0.8 for the LOAD, indicating an excellent cut-off point.
conclusionOur estimates of MCIDs for dogs with OA were consistent with previously proposed values of -4 for the LOAD and -14 for the COI in a post-surgical intervention context. ROC curve data suggest that LOAD may more reliably differentiate between anchor groups. We also presented estimates from COI of -4 for Stiffness, Function, and Gait and -3 for quality of life. These estimates can be used for research and patient monitoring.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.