Evidence map›Paper›PMID 37729017›Full record

ArticleMolecular biology of the cell2023

CRISPR-mediated reversion of oncogenic KRAS mutation results in increased proliferation and reveals independent roles of Ras and mTORC2 in the migration of A549 lung cancer cells.

Alyssa N Werner, Avani I Kumar, Pascale G Charest

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alyssa N WernerDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721.
Avani I KumarDepartment of Chemistry and Biochemistry, University of Arizona, Tucson, AZ 85721.
Pascale G CharestDepartment of Molecular and Cellular Biology, University of Arizona, Tucson, AZ 85721.
University of Arizona · US

Funding

CHEMISTRY-BIOLOGY INTERFACE TRAINING PROGRAMT32GM008804 · NIGMS · UNIVERSITY OF ARIZONA · PI MONTFORT, WILLIAM R. · 2003 to 2023
$3.9M
The role and regulation of mTORC2 in cell migrationR01GM131200 · NIGMS · UNIVERSITY OF ARIZONA · PI CHAREST, PASCALE G · 2019 to 2023
$1.6M
NIGMS NIH HHS R01 GM131200NIGMS NIH HHS T32 GM008804
6 · The paper itself

Abstract

Although the

Indexed as

DictyosteliumLung NeoplasmsA549 CellsAnimalsCell Line, TumorCell ProliferationGenes, rasHumansMammalsMechanistic Target of Rapamycin Complex 2MutationProto-Oncogene Proteins p21(ras)KRAS protein, humanMechanistic Target of Rapamycin Complex 2Proto-Oncogene Proteins p21(ras)

Identifiers

PMID37729017
PMCPMC10848948
OpenAlexW4386886557

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.