Evidence map›Paper›PMID 37728844›Full record

ArticleGenes & genomics2024

LncRNA LINC01123 promotes malignancy of ovarian cancer by targeting hsa-miR-516b-5p/VEGFA.

Bing Dong, Cuiping Li, Xiaomeng Xu, Yan Wang, Yuewen Li, Xingmei Li

Abstract read
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In one paragraph

Article in Genes & genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Bing DongDepartment of Gynaecology, The Third Affiliated Hospital of Qiqihar Medical University, No. 27, Taishun Street, Tiefeng, Qiqihar, 161000, Heilongjiang, China. db0301@163.com.
Cuiping LiDepartment of Gynaecology, The Third Affiliated Hospital of Qiqihar Medical University, No. 27, Taishun Street, Tiefeng, Qiqihar, 161000, Heilongjiang, China.
Xiaomeng XuDepartment of Gynaecology, The Third Affiliated Hospital of Qiqihar Medical University, No. 27, Taishun Street, Tiefeng, Qiqihar, 161000, Heilongjiang, China.
Yan WangDepartment of Gynaecology, The Third Affiliated Hospital of Qiqihar Medical University, No. 27, Taishun Street, Tiefeng, Qiqihar, 161000, Heilongjiang, China.
Yuewen LiDepartment of Gynaecology, The Third Affiliated Hospital of Qiqihar Medical University, No. 27, Taishun Street, Tiefeng, Qiqihar, 161000, Heilongjiang, China.
Xingmei LiDepartment of Gynaecology, The Third Affiliated Hospital of Qiqihar Medical University, No. 27, Taishun Street, Tiefeng, Qiqihar, 161000, Heilongjiang, China.
Qiqihar Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLong non-coding RNAs (lncRNAs) play a critical role in the development of ovarian cancer (OC).

objectiveThe study aimed to determine the role of LncRNA LINC01123 in OC bio-progression, which is upregulated in OC tissues during OC progression.

methodsBioinformatics methods, GEPIA, and qRT-PCR were used to reveal the level and correlation of LINC01123, hsa-miR-516b-5p, and VEGFA, in OC cell lines. MTT, EdU, TUNEL, and Transwell assays were performed to assess the bioactivity of OC cell. Target sites of LINC01123 and hsa-miR-516b-5p were predicted using Starbase, and the potential linkage points of VEGFA and hsa-miR-516b-5p were predicted using TargetScan. These sites and linkage points were confirmed by double luciferase reporter assay.

resultsLINC01123 was upregulated in OC cell lines and LINC01123 silencing suppressed the proliferation and metastasis of OC cells, but promoted cell apoptosis. hsa-miR-516b-5p was linked to LINC01123 and. VEGFA was downstream of hsa-miR-516b-5p. Importantly, silencing of hsa-miR-516b-5p reversed the inhibitory impact of si-LINC01123. The result of hsa-miR-516b-5p inhibitor + si-LINC01123 co-transfection were rescued by si-VEGFA.

conclusionLINC01123 promotes OC development by dampening miR-516b-5p function, and may be a novel target for treating OC.

Indexed as

MicroRNAsOvarian NeoplasmsRNA, Long NoncodingApoptosisCell LineFemaleHumansVascular Endothelial Growth Factor AMicroRNAsRNA, Long NoncodingVascular Endothelial Growth Factor AVEGFA protein, humanHsa-miR-516b-5pLINC01123Long non-coding RNAOvarian cancerVEGFA

Identifiers

PMID37728844
OpenAlexW4386878134

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.