Evidence map›Paper›PMID 37728771›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2024

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Severin Mairinger, Sarah Leterrier, Thomas Filip, Mathilde Löbsch, Jens Pahnke, Irene Hernández-Lozano, Johann Stanek, Nicolas Tournier, Markus Zeitlinger, Marcus Hacker and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Imaging the Activity of Efflux Transporters at the Blood-Brain Barrier in Neurologic Diseases: Radiotracer Selection Criteria.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Review
  2. Article
  3. [Fluids and barriers of the CNS · 2024
    Article
  4. Performance and Sensitivity of [Molecular pharmaceutics · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 6 countries.

Severin MairingerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Sarah LeterrierLaboratoire d'Imagerie Biomédicale Multimodale (BIOMAPS), Université Paris-Saclay, CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Orsay, France.
Thomas FilipCore Facility Laboratory Animal Breeding and Husbandry, Medical University of Vienna, Vienna, Austria.
Mathilde LöbschCore Facility Laboratory Animal Breeding and Husbandry, Medical University of Vienna, Vienna, Austria.
Jens PahnkeDepartment of Pathology, Section of Neuropathology Research, University of Oslo (UiO) and Oslo University Hospital (OUS), Oslo, Norway.
Irene Hernández-LozanoDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Johann StanekDepartment of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Nicolas TournierLaboratoire d'Imagerie Biomédicale Multimodale (BIOMAPS), Université Paris-Saclay, CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Orsay, France.
Markus ZeitlingerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Marcus HackerDepartment of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Oliver LangerDepartment of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
Thomas WanekDepartment of Biomedical Imaging and Image-Guided Therapy, Medical University of Vienna, Vienna, Austria.
Medical University of Vienna · ATCEA Paris-Saclay · FRCommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRUniversity of Oslo · NOUniversity of Veterinary Medicine Vienna · AT

Funding

Austrian Science Fund FWF I 4470
6 · The paper itself

Abstract

The efflux transporter P-glycoprotein (P-gp) at the blood-brain barrier limits the cerebral uptake of various xenobiotics. To assess the sensitivity of [

Indexed as

ATP Binding Cassette Transporter, Subfamily B, Member 1Blood-Brain BarrierAnimalsATP Binding Cassette Transporter, Subfamily BBrainMetoclopramideMicePositron-Emission TomographyATP Binding Cassette Transporter, Subfamily BATP Binding Cassette Transporter, Subfamily B, Member 1Metoclopramide[11C]metoclopramideblood-brain barrierheterozygous Abcb1a/b knockout micePETP-glycoprotein

Identifiers

PMID37728771
PMCPMC10905639
OpenAlexW4386877835

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.